Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

Base Information

Chemical Name:Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate
CAS No.:193400-52-1
Molecular Formula:C10H10N2O2S
Molecular Weight:222.26400
Hs Code.:2934999090
DSSTox Substance ID:DTXSID60355129
Wikidata:Q82133797
ChEMBL ID:CHEMBL4464293
Mol file:193400-52-1.mol

Synonyms:methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate;193400-52-1;methyl 3-amino-6-methylthiopheno[2,3-b]pyridine-2-carboxylate;CHEMBL4464293;Methyl 3-amino-6-methylthiophene[2,3-b]pyridine-2-carboxylate;SCHEMBL8558549;DTXSID60355129;Methyl3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate;BDBM50512250;MFCD00245707;STK978262;TD8005;AKOS000667888;FS-1269;CS-0084895;FT-0732193;EN300-227048;AB00079227-01;A880268;AM-807/25050026;SR-01000507922;SR-01000507922-1;Z1509469877;Thieno[2,3-b]pyridine-2-carboxylic acid, 3-aMino-6-Methyl-, Methyl ester

Suppliers and Price of Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate 95+%
5g
$ 437.00

Chemcia Scientific
3-Amino-6-methyl-thieno[2,3-b]pyridine-2-carboxylicacidmethylester 95%
5 G
$ 785.00

Alichem
Methyl3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate
1g
$ 282.24

AK Scientific
Methyl3-amino-6-methyl-thieno[2,3-b]pyridine-2-carboxylate
1g
$ 117.00

Total 12 raw suppliers

Chemical Property of Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

PSA：93.45000
LogP:2.55470
Storage Temp.:2-8°C
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:222.04629874
Heavy Atom Count:15
Complexity:262

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(C=C1)C(=C(S2)C(=O)OC)N

Technology Process of Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

There total 3 articles about Methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 28900-10-9
2-chloro-6-methylnicotinonitrile

: 2365-48-2
Methyl thioglycolate

: 193400-52-1
methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: 2-chloro-6-methylnicotinonitrile; Methyl thioglycolate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

With sodium methylate; In methanol; at 20 ℃; for 1h;
DOI:10.5560/ZNB.2014-3320

Reference yield:

: 4241-27-4
1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile

: 193400-52-1
methyl 3-amino-6-methylthieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trichlorophosphate / 24 h / 60 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2.2: 1 h / 20 °C

With potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.5560/ZNB.2014-3320