3-Thiophenecarboxylic acid, 2-amino-5-[4-(phenylmethoxy)phenyl]-4-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

Base Information

• Chemical Name: 3-Thiophenecarboxylic acid, 2-amino-5-[4-(phenylmethoxy)phenyl]-4-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester
• CAS No.: 193698-02-1
• Molecular Formula: C33H29NO4S
• Molecular Weight: 535.664
• Mol file: 193698-02-1.mol

Synonyms:

Chemical Property of 3-Thiophenecarboxylic acid, 2-amino-5-[4-(phenylmethoxy)phenyl]-4-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Thiophenecarboxylic acid, 2-amino-5-[4-(phenylmethoxy)phenyl]-4-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

There total 6 articles about 3-Thiophenecarboxylic acid, 2-amino-5-[4-(phenylmethoxy)phenyl]-4-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(4-Benzyloxy-benzyl)-4-(4-benzyloxy-phenyl)-2-cyano-but-2-enoic acid methyl ester (193698-00-9) → 2-Amino-4-(4-benzyloxy-benzyl)-5-(4-benzyloxy-phenyl)-thiophene-3-carboxylic acid methyl ester (193698-02-1)

Guidance literature:

With sulfur; diisopropylamine; In ethanol; at 60 ℃; for 1h;

DOI:10.1016/S0960-894X(97)00283-7

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 2-Amino-4-(4-benzyloxy-benzyl)-5-(4-benzyloxy-phenyl)-thiophene-3-carboxylic acid methyl ester (193698-02-1)

Guidance literature:

Multi-step reaction with 5 steps

2: LDA / tetrahydrofuran / 24 h / -78 - 25 °C

3: 87 percent / 10percent HCl / ethanol / 24 h / Heating

4: 66 percent / NH₄OAc, HOAc / benzene / 3 h / Heating

5: 83 percent / S₈, i-Pr₂NH / ethanol / 1 h / 60 °C

With hydrogenchloride; sulfur; ammonium acetate; acetic acid; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; benzene;

DOI:10.1016/S0960-894X(97)00283-7

Reference yield:

(4-benzyloxy-phenyl)-acetic acid methyl ester (68641-16-7) → 2-Amino-4-(4-benzyloxy-benzyl)-5-(4-benzyloxy-phenyl)-thiophene-3-carboxylic acid methyl ester (193698-02-1)

Guidance literature:

Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran / 24 h / -78 - 25 °C

2: 87 percent / 10percent HCl / ethanol / 24 h / Heating

3: 66 percent / NH₄OAc, HOAc / benzene / 3 h / Heating

4: 83 percent / S₈, i-Pr₂NH / ethanol / 1 h / 60 °C

With hydrogenchloride; sulfur; ammonium acetate; acetic acid; diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; ethanol; benzene;

DOI:10.1016/S0960-894X(97)00283-7

upstream raw materials:

3-(4-Benzyloxy-benzyl)-4-(4-benzyloxy-phenyl)-2-cyano-but-2-enoic acid methyl ester

Methyl 4-hydroxyphenylacetate

(4-benzyloxy-phenyl)-acetic acid methyl ester

benzyl bromide