2-Butenoic acid, 2-cyano-4-[4-(phenylmethoxy)phenyl]-3-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

Base Information

• Chemical Name: 2-Butenoic acid, 2-cyano-4-[4-(phenylmethoxy)phenyl]-3-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester
• CAS No.: 193698-00-9
• Molecular Formula: C33H29NO4
• Molecular Weight: 503.598
• Mol file: 193698-00-9.mol

Synonyms:

Chemical Property of 2-Butenoic acid, 2-cyano-4-[4-(phenylmethoxy)phenyl]-3-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Butenoic acid, 2-cyano-4-[4-(phenylmethoxy)phenyl]-3-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester

There total 5 articles about 2-Butenoic acid, 2-cyano-4-[4-(phenylmethoxy)phenyl]-3-[[4-(phenylmethoxy)phenyl]meth yl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,3-bis<4-(benzyloxy)phenyl>propan-2-one (138434-75-0) + methyl 2-cyanoacetate (105-34-0) → 3-(4-Benzyloxy-benzyl)-4-(4-benzyloxy-phenyl)-2-cyano-but-2-enoic acid methyl ester (193698-00-9)

Guidance literature:

With ammonium acetate; acetic acid; In benzene; for 3h; Heating;

DOI:10.1016/S0960-894X(97)00283-7

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 3-(4-Benzyloxy-benzyl)-4-(4-benzyloxy-phenyl)-2-cyano-but-2-enoic acid methyl ester (193698-00-9)

Guidance literature:

Multi-step reaction with 4 steps

2: LDA / tetrahydrofuran / 24 h / -78 - 25 °C

3: 87 percent / 10percent HCl / ethanol / 24 h / Heating

4: 66 percent / NH₄OAc, HOAc / benzene / 3 h / Heating

With hydrogenchloride; ammonium acetate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; benzene;

DOI:10.1016/S0960-894X(97)00283-7

Reference yield:

(4-benzyloxy-phenyl)-acetic acid methyl ester (68641-16-7) → 3-(4-Benzyloxy-benzyl)-4-(4-benzyloxy-phenyl)-2-cyano-but-2-enoic acid methyl ester (193698-00-9)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / 24 h / -78 - 25 °C

2: 87 percent / 10percent HCl / ethanol / 24 h / Heating

3: 66 percent / NH₄OAc, HOAc / benzene / 3 h / Heating

With hydrogenchloride; ammonium acetate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; benzene;

DOI:10.1016/S0960-894X(97)00283-7

upstream raw materials:

1,3-bis<4-(benzyloxy)phenyl>propan-2-one

methyl 2-cyanoacetate

Methyl 4-hydroxyphenylacetate

(4-benzyloxy-phenyl)-acetic acid methyl ester

Downstream raw materials:

2-Amino-4-(4-benzyloxy-benzyl)-5-(4-benzyloxy-phenyl)-thiophene-3-carboxylic acid methyl ester