1-(Benzoylamino)methyl-3,4-dihydro isoquinoline

Base Information

Chemical Name:1-(Benzoylamino)methyl-3,4-dihydro isoquinoline
CAS No.:19382-36-6
Molecular Formula:C17H14N2O
Molecular Weight:262.311
Hs Code.:
DSSTox Substance ID:DTXSID70563793
Wikidata:Q82448283

Synonyms:1-(BENZOYLAMINO)METHYL-3,4-DIHYDRO ISOQUINOLINE;132056-76-9;19382-36-6;1-(Benzoylamino)Methyl-3,4-Dihydro-Iso-Quinoline;N-(3,4-dihydroisoquinolin-1-ylmethyl)benzamide;N-[(3,4-Dihydroisoquinolin-1-yl)methyl]benzamide;DTXSID70563793;2-Amino-1-(4 inverted exclamation mark -chlorophenyl)propan-1-ol

Suppliers and Price of 1-(Benzoylamino)methyl-3,4-dihydro isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Benzoylamino)methyl-3,4-dihydro isoquinoline

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:264.126263138
Heavy Atom Count:20
Complexity:371

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN=C(C2=CC=CC=C21)CNC(=O)C3=CC=CC=C3

Technology Process of 1-(Benzoylamino)methyl-3,4-dihydro isoquinoline

There total 4 articles about 1-(Benzoylamino)methyl-3,4-dihydro isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 113883-31-1,142052-74-2
4-(1-Isoquinolyl)-2-phenyl-2-oxazolin-5-one

: 19382-36-6
N-(isoquinolin-1-ylmethyl)benzamide

Guidance literature:: With potassium carbonate; In ethanol; water; for 5h; Heating;

Reference yield: 48.0%

: 98-88-4
benzoyl chloride

: 40615-08-5
[(isoquinolin-1-yl)methyl]amine

: 19382-36-6
N-(isoquinolin-1-ylmethyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol400870b

Reference yield:

: 1198-30-7
1-isoquinolinecarbonitrile

: 19382-36-6
N-(isoquinolin-1-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / acetic acid / 6 h / 20 °C / 10343.2 Torr / Autoclave

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In dichloromethane; acetic acid;
DOI:10.1021/ol400870b