40615-08-5

Basic information

• Product Name: 1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE
• Synonyms: ISOQUINOLIN-1-YL-METHYLAMINE;CBI-BB ZERO/005368;C-ISOQUINOLIN-1-YL-METHYLAMINE;1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE;RARECHEM AL BW 1594;C-Isoquinolin-1-yl-methylamine 2HCl;I80132;1-Isoquinolin-1-ylmethanamine
• CAS NO: 40615-08-5
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.2
• Mol File: 40615-08-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 315°Cat760mmHg
• Flash Point: 164.9°C
• Appearance: /
• Density: 1.156
• Vapor Pressure: 0.000451mmHg at 25°C
• Refractive Index: 1.662
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.70±0.30(Predicted)
• CAS DataBase Reference: 1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE(40615-08-5)
• EPA Substance Registry System: 1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE(40615-08-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 40615-08-5(Hazardous Substances Data)

Usage

General Description

1-ISOQUINOLIN-1-YLMETHANAMINE DIHYDROCHLORIDE is a chemical compound with potential pharmaceutical applications. It belongs to the class of isoquinoline alkaloids and is derived from isoquinoline. The dihydrochloride salt form of this compound has enhanced solubility, making it more suitable for use in pharmaceutical formulations. It is being studied for its potential as a therapeutic agent for neurological disorders, as it has been shown to have neuroprotective and anti-inflammatory properties. Additionally, it has been investigated for its potential in treating addiction and substance abuse. The compound is still in the experimental stage and further research is being conducted to determine its full range of potential applications.

InChI:InChI=1/C10H10N2/c11-7-10-9-4-2-1-3-8(9)5-6-12-10/h1-6H,7,11H2

Upstream product

• 1198-30-7 1-isoquinolinecarbonitrile 
• 27311-65-5 1-chloromethyl-isoquinoline 
• 1355450-11-1 N-(1-isoquinolylmethyl)phthalimide 
• 1532-72-5 isoquinoline N-oxide 
• 119-65-3 isoquinoline 
• 123026-29-9 imidazolyl-1-isoquinolinylmethanone 
• 1436-44-8 isoquinoline-1-carboxamide 
• 486-73-7 1-isoquinolinecarboxylic acid 

Downstream Products

• 1354688-24-6 (acetate)Cu(bis(1-isoquinolylcarbonyl)amide) 
• 1355450-12-2 tris(1-isoquinolylmethyl)amine 
• 79848-93-4 N-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)cyclohexanecarboxylic acid amide 
• 135526-78-2 (-)-Praziquantel 
• 60567-47-7 (S)-1-[(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide 
• 765915-89-7 N-[(R)-1-(1,2,3,4-tetrahydroisoquinolin-1-ylmethyl)]cyclohexanecarboxylic acid amide 
• 19382-37-7 3-phenylimidazo<5,1-a>isoquinoline 
• 19382-36-6 N-(isoquinolin-1-ylmethyl)benzamide 
• 1173997-55-1 C₁₇H₁₅N₃S 
• 1214174-14-7 C₂₀H₁₆N₂O₂ 
• 1025965-13-2 C₂₈H₂₂N₄O 

Relevant articles and documents

MANUFACTURING METHOD OF OPTICAL ACTIVE SECONDARY ALCOHOL

PROBLEM TO BE SOLVED: To provide a method for manufacturing optical active secondary alcohol with high optical purity by hydrogenating a substrate carbonyl compound using a ruthenium complex with a specific optical active diphosphine compound and an amine compound of which synthesis is easy as ligands as a catalyst. SOLUTION: The manufacturing method of optical active secondary alcohol including reacting a substrate carbonyl compound (excluding 3-quinuclidinone, a 3-quinuclidinone derivative having a substituent, and ketone having an aromatic hydrocarbon group and a heterocycle) with hydrogen and/or a hydrogen-donating compound in a presence of a ruthenium complex selected from a compound represented by the following general formula (1) RuXYAB (1) [X and Y are same or different, represent a hydrogen atom or an anionic group, A represents optical active diphosphine represented by the general formula (2), and B represents an amine compound represented by the following general formula (3)]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL

[Object] The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. [Solution] The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

Zinc-specific fluorescent response of tris(isoquinolylmethyl)amines (isoTQAs)

Isoquinoline-based tetradentate ligands with C3-symmetry, tris(1- or 3-isoquinolylmethyl)amine (1- or 3-isoTQA), have been prepared and their zinc-induced fluorescence enhancement was investigated. Upon excitation at 324 nm, 1-isoTQA shows very weak fluorescence (β = ～0.003) in DMF/H2O (1/1) solution. In the presence of zinc ion, 1-isoTQA exhibits fluorescence increase (β = 0.041) at 359 and 470 nm. This fluorescence enhancement at 470 nm is specific for zinc. However, 3-isoTQA exhibited a smaller fluorescence enhancement upon zinc complexation (β = 0.017, λem = 360 and 464 nm) compared with 1-isoTQA. Crystal structures of zinc complexes of isoTQAs demonstrate the diminished steric crowding and shorter Zn-Naromatic distances compared with isoTQENs (N,N,N′,N′-tetrakis(isoquinolylmethyl)ethylenediamines) leads to a higher fluorescent response toward zinc relative to cadmium.