1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-

Base Information

Chemical Name:1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-
CAS No.:91857-94-2
Molecular Formula:C₉H₈FN₃
Molecular Weight:177.181
Hs Code.:
DSSTox Substance ID:DTXSID001286863

Synonyms:91857-94-2;1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-;4-Amino-5-(p-fluorophenyl)pyrazole;Pyrazole, 4-amino-5-(p-fluorophenyl)-;3-(4-Fluorophenyl)-1H-pyrazol-4-amine;SCHEMBL695297;DTXSID001286863;AKOS010654504;EN300-1776087

Suppliers and Price of 1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:177.07022543
Heavy Atom Count:13
Complexity:168

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=C(C=NN2)N)F

Technology Process of 1H-Pyrazol-4-amine, 3-(4-fluorophenyl)-

There total 1 articles about 1H-Pyrazol-4-amine, 3-(4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253734-03-0
2-[2-dimethylamino-1-(4-fluorobenzoyl)-vinyl]isoindole-1,3-dione

: 91857-94-2
3-(4-fluorophenyl)-1H-pyrazol-4-ylamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere; Reflux;

Reference yield:

: 91857-94-2
3-(4-fluorophenyl)-1H-pyrazol-4-ylamine

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253734-04-1
2,6-difluoro-N-[5-(4-fluorophenyl)-1H-pyrazol-4-yl]benzamide

: 1253734-05-2
N-(1-(2,6-difluorobenzoyl)-5-(4-fluorophenyl)-1H-pyrazol-4-yl]-2,6-difluorobenzamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 91857-94-2
3-(4-fluorophenyl)-1H-pyrazol-4-ylamine

: 1253734-08-5
3-bromo-5-(2,6-difluorophenyl)-7-fluoro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; methanol / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3: potassium hydroxide; bromine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

With methanol; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;