5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

Base Information

Chemical Name:5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline
CAS No.:1253734-02-9
Molecular Formula:C₂₂H₂₀F₃N₅O₂S
Molecular Weight:475.494
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

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Chemical Property of 5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

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Technology Process of 5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

There total 7 articles about 5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253734-09-6
5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazolo[4,3-c]isoquinoline

: 1253734-02-9
5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 20h; Inert atmosphere;

Reference yield:

: 18063-02-0
2,6-difluorobenzoylchloride

: 1253734-02-9
5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; methanol / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: 1,4-dioxane / 0.17 h / Inert atmosphere

5.2: 5 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

With methanol; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 91857-94-2
3-(4-fluorophenyl)-1H-pyrazol-4-ylamine

: 1253734-02-9
5-(2,6-difluorophenyl)-7-fluoro-3-{[1-(methylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; methanol / water; tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: 1,4-dioxane / 0.17 h / Inert atmosphere

5.2: 5 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

With methanol; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;