Benzene, 1-bromo-2-(1-pentynyl)-

Base Information

• Chemical Name: Benzene, 1-bromo-2-(1-pentynyl)-
• CAS No.: 194092-09-6
• Molecular Formula: C11H11Br
• Molecular Weight: 223.112
• Mol file: 194092-09-6.mol

Synonyms:

Chemical Property of Benzene, 1-bromo-2-(1-pentynyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-bromo-2-(1-pentynyl)-

There total 1 articles about Benzene, 1-bromo-2-(1-pentynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Pentyne (627-19-0) + 1-Bromo-2-iodobenzene (583-55-1) → 1-bromo-2-(n-propylethynyl)benzene (194092-09-6)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c6cc00635c

Reference yield: 90.0%

Chloro(chloromethyl)dimethylsilane (1719-57-9) + 1-bromo-2-(n-propylethynyl)benzene (194092-09-6) → C14H19ClSi

Guidance literature:

1-bromo-2-(n-propylethynyl)benzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.666667h; Inert atmosphere;

Chloro(chloromethyl)dimethylsilane; In tetrahydrofuran; pentane; at -78 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c6cc00635c

Reference yield: 89.0%

2,6-dimethylaniline (87-62-7) + 1-bromo-2-(n-propylethynyl)benzene (194092-09-6) → 1-(2,6-dimethyl-phenyl)-2-propyl-1H-indole (1384966-46-4)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; OTips-DalPhos; potassium tert-butylate; In toluene; at 90 ℃; for 12h; Inert atmosphere; Sealed vial;

DOI:10.1039/c2cc33071g

upstream raw materials:

1-Pentyne

1-Bromo-2-iodobenzene

Downstream raw materials:

1-(trimethylsilylethynyl)-2-(pent-1-ynyl)benzene

1-ethynyl-2-(pent-1-yn-1-yl)benzene

1,5-bis[2-(pent-1-ynyl)phenyl]ethynyl-2,4-dibromobenzene

1,4-bis[2-(pent-1-ynyl)phenyl]ethynyl-2,5-dibromobenzene

Refernces

• 1、 Arndt, Sebastian,Hansmann, Max M.,Motloch, Petr,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.. "Intramolecular anti-Phosphinoauration of Alkynes: An FLP-Motivated Approach to Stable Aurated Phosphindolium Complexes". supporting information. p. 2542 - 2547. Retrieved 2017/03/06.
• 2、 Zheng, Guangfan,Zhao, Jinbo,Li, Zhanyu,Zhang, Qiao,Sun, Jiaqiong,Sun, Haizhu,Zhang, Qian. "Highly Regio and Stereoselective Intermolecular Seleno- and Thioamination of Alkynes". supporting information. p. 3513 - 3518. Retrieved 2016/03/05.