Technology Process of 4-Pentynoic acid, 2-hydroxy-, (2R)-
There total 1 articles about 4-Pentynoic acid, 2-hydroxy-, (2R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sulfuric acid; sodium nitrite;
at 0 - 23 ℃;
DOI:10.1021/jm030166l
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: HCl / dioxane / 16 h / 23 °C
2.1: 2,6-lutidine / CH2Cl2 / 0.42 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 23 °C
3.2: 0.776 g / tetrahydrofuran / 0.5 h / 23 °C
4.1: lithium iodide; pyridine / 0.5 h / Heating
5.1: HCl / dioxane / 2 h / 23 °C
5.2: 1.16 g / 1-hydroxybenzotriazole hydrate; diisopropylethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2 / 16 h / 23 °C
6.1: Dess-Martin periodinane / CH2Cl2 / 1.25 h / 23 °C
With
pyridine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydride; Dess-Martin periodane; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm030166l
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: HCl / dioxane / 16 h / 23 °C
2.1: 2,6-lutidine / CH2Cl2 / 0.42 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / 0.5 h / 23 °C
3.2: 0.776 g / tetrahydrofuran / 0.5 h / 23 °C
4.1: lithium iodide; pyridine / 0.5 h / Heating
5.1: 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH2Cl2 / 23 °C
With
pyridine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium iodide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm030166l