2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-

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Chemical Name:2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-
CAS No.:629625-70-3
Molecular Formula:C37H43N5O9
Molecular Weight:701.777
Hs Code.:

2-Pentenoic acid,
5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[
3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo-
4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-

Synonyms:

Suppliers and Price of 2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-

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Chemical Property of 2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-

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Technology Process of 2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)-

There total 9 articles about 2-Pentenoic acid, 5-[(3S)-1-[(2,4-dimethoxyphenyl)methyl]-2-oxo-3-pyrrolidinyl]-4-[[(2S)-2-[ 3-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-2-oxo-1(2H)-pyridinyl]-1-oxo- 4-pentynyl]amino]-, 1,1-dimethylethyl ester, (2E,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 23235-01-0,23235-03-2,50428-03-0,64165-64-6
(R)-2-aminopent-4-ynoic acid

: 629625-70-3
trans-(2'''S,3'S,4S)-5-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-yl]-4-(2'''-{3''''-[(5'''''-methylisoxazole-3'''''-carbonyl)amino]-2''''-oxo-2''''H-pyridin-1''''-yl}pent-4'''-ynoylamino)pent-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: aq. sodium nitrite; H₂SO₄ / 0 - 23 °C

2.1: HCl / dioxane / 16 h / 23 °C

3.1: 2,6-lutidine / CH₂Cl₂ / 0.42 h / 0 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 23 °C

4.2: 0.776 g / tetrahydrofuran / 0.5 h / 23 °C

5.1: lithium iodide; pyridine / 0.5 h / Heating

6.1: HCl / dioxane / 2 h / 23 °C

6.2: 1.16 g / 1-hydroxybenzotriazole hydrate; diisopropylethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / 23 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 1.25 h / 23 °C

8.1: 0.844 g / tetrahydrofuran / 0.75 h / Heating

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; sulfuric acid; sodium hydride; Dess-Martin periodane; lithium iodide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm030166l

Reference yield:

: 223526-33-8
(1S,3'S)-<2-<1'-(2'',4''-dimethoxybenzyl)-2'-oxo-pyrrolidin-3'-yl>-1-hydroxymethylethyl>-carbamic acid tert-butyl ester

: 629625-70-3
trans-(2'''S,3'S,4S)-5-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-yl]-4-(2'''-{3''''-[(5'''''-methylisoxazole-3'''''-carbonyl)amino]-2''''-oxo-2''''H-pyridin-1''''-yl}pent-4'''-ynoylamino)pent-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: HCl / dioxane / 2 h / 23 °C

1.2: 1.16 g / 1-hydroxybenzotriazole hydrate; diisopropylethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / 23 °C

2.1: Dess-Martin periodinane / CH₂Cl₂ / 1.25 h / 23 °C

3.1: 0.844 g / tetrahydrofuran / 0.75 h / Heating

With hydrogenchloride; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm030166l

Reference yield:

: 194864-95-4
(R)-2-hydroxypent-4-ynoic acid

: 629625-70-3
trans-(2'''S,3'S,4S)-5-[1'-(2'',4''-dimethoxybenzyl)-2'-oxopyrrolidin-3'-yl]-4-(2'''-{3''''-[(5'''''-methylisoxazole-3'''''-carbonyl)amino]-2''''-oxo-2''''H-pyridin-1''''-yl}pent-4'''-ynoylamino)pent-2-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: HCl / dioxane / 16 h / 23 °C

2.1: 2,6-lutidine / CH₂Cl₂ / 0.42 h / 0 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 23 °C

3.2: 0.776 g / tetrahydrofuran / 0.5 h / 23 °C

4.1: lithium iodide; pyridine / 0.5 h / Heating

5.1: HCl / dioxane / 2 h / 23 °C

5.2: 1.16 g / 1-hydroxybenzotriazole hydrate; diisopropylethylamine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 16 h / 23 °C

6.1: Dess-Martin periodinane / CH₂Cl₂ / 1.25 h / 23 °C

7.1: 0.844 g / tetrahydrofuran / 0.75 h / Heating

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; sodium hydride; Dess-Martin periodane; lithium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm030166l