ethyl 5,6-difluoro-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 5,6-difluoro-1H-indole-2-carboxylate
CAS No.:169674-34-4
Molecular Formula:C11H9F2NO2
Molecular Weight:225.19
Hs Code.:
DSSTox Substance ID:DTXSID70597134
Wikidata:Q72463032
Mol file:169674-34-4.mol

Synonyms:169674-34-4;ethyl 5,6-difluoro-1H-indole-2-carboxylate;Ethyl 5,6-difluoro-2-indolecarboxylate;5,6-Difluoro-2-indole carboxylic acid ether ester;MFCD08458979;5,6-Difluoro-2-indolecarboxylic acid ether ester;ethyl 5,6-difluoroindole-2-carboxylate;SCHEMBL8959587;1H-Indole-2-carboxylic acid, 5,6-difluoro-, ethyl ester;DTXSID70597134;OVSOYWROLOCQIS-UHFFFAOYSA-N;BCP23332;AKOS015898579;PB41199;AS-79090;SY262176;AM20030133;CS-0054242;A847705;Q-103554;5,6-Difluoro-1H-indole-2-carboxylic acid ethyl ester

Suppliers and Price of ethyl 5,6-difluoro-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5,6-Difluoro-2-indolecarboxylicAcidetherester
10mg
$ 110.00

TRC
5,6-Difluoro-2-indolecarboxylicAcidetherester
1mg
$ 45.00

Matrix Scientific
Ethyl 5,6-difluoro-2-indolecarboxylate 95+%
1g
$ 1260.00

Matrix Scientific
Ethyl 5,6-difluoro-2-indolecarboxylate 95+%
250mg
$ 567.00

Crysdot
Ethyl5,6-difluoro-2-indolecarboxylate 95+%
1g
$ 455.00

Crysdot
Ethyl5,6-difluoro-2-indolecarboxylate 95+%
5g
$ 1365.00

Chemenu
Ethyl5,6-difluoro-2-indolecarboxylate 95%
5g
$ 1277.00

Chemenu
Ethyl5,6-difluoro-2-indolecarboxylate 95%
1g
$ 426.00

American Custom Chemicals Corporation
5,6-DIFLUORO-2-INDOLE CARBOXYLIC ACID ETHER ESTER 95.00%
5MG
$ 500.13

Alichem
Ethyl5,6-difluoro-2-indolecarboxylate
5g
$ 1351.35

Total 21 raw suppliers

Chemical Property of ethyl 5,6-difluoro-1H-indole-2-carboxylate

Chemical Property:

Vapor Pressure:4.18E-05mmHg at 25°C
Refractive Index:1.581
Boiling Point:351.2 °C at 760 mmHg
Flash Point:166.2 °C
PSA：42.09000
Density:1.367 g/cm³
LogP:2.62280
Storage Temp.:2-8°C
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:225.06013485
Heavy Atom Count:16
Complexity:275

Purity/Quality:

99%, ^*data from raw suppliers

5,6-Difluoro-2-indolecarboxylicAcidetherester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC2=CC(=C(C=C2N1)F)F

Technology Process of ethyl 5,6-difluoro-1H-indole-2-carboxylate

There total 2 articles about ethyl 5,6-difluoro-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 617-35-6
2-oxo-propionic acid ethyl ester

: 40594-37-4,875664-54-3
(3,4-difluorophenyl)phenylhydrazine hydrochloride

: 194870-66-1
ethyl 4,5-difluoro-1H-indole-2-carboxylate

: 169674-34-4
ethyl 5,6-difluoro-1H-indole-2-carboxylate

Guidance literature:: 2-oxo-propionic acid ethyl ester; (3,4-difluorophenyl)phenylhydrazine hydrochloride; In ethanol; for 12h; Reflux;

With phosphoric acid; In ethanol; at 75 - 80 ℃; for 0.166667h; Overall yield = 4.98 g;

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 3863-11-4
3,4-difluoroaniline

: 194870-66-1
ethyl 4,5-difluoro-1H-indole-2-carboxylate

: 169674-34-4
ethyl 5,6-difluoro-1H-indole-2-carboxylate

Guidance literature:: 3,4-difluoroaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.666667h;

With sodium acetate; In water; for 0.5h;

2-acetylpropanoic acid ethyl ester; With potassium acetate; more than 3 stages;