1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester

Base Information

• Chemical Name: 1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester
• CAS No.: 194924-95-3
• Molecular Formula: C11H17NO5
• Molecular Weight: 243.25600
• Hs Code.: 2933990090
• Mol file: 194924-95-3.mol

Synonyms:1-tert-Butyl 3-methyl 4-oxopyrrolidine-1,3-dicarboxylate;METHYL 1-TERT-BUTYLOXYCARBONYL-4-OXOPYRROLIDINE-3-CARBOXYLATE;

Chemical Property of 1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester

Chemical Property:

• PSA: 72.91000
• LogP: 0.53330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl1-tert-butyloxycarbonyl-4-oxopyrrolidine-3-carboxylate 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester

There total 2 articles about 1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(tert-butoxycarbonyl)glycine methyl ester (31954-27-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 4-oxopyrrolidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester (194924-95-3)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 23 ℃; for 16h; Inert atmosphere; Cooling with ice;

DOI:10.1055/s-0030-1258419

Reference yield: 60.0%

3-(tert-Butoxycarbonyl-methoxycarbonylmethyl-amino)-propionic acid methyl ester → Methyl 1-(tert-butoxycarbonyl)-3-oxopyrrolidine-2-carboxylate (130948-04-8) + 4-oxopyrrolidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester (194924-95-3)

Guidance literature:

With potassium tert-butylate; In toluene; at 0 ℃; for 0.5h; Yields of byproduct given;

Reference yield: 77.0%

(2S)-2-amino-N,N-diethyl-3-methylbutanamide (56414-87-0) + 4-oxopyrrolidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester (194924-95-3) → N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide (1309676-07-0)

Guidance literature:

With hydrogenchloride; In water; toluene; at 60 ℃; for 16h; Molecular sieve; Inert atmosphere;

DOI:10.1055/s-0030-1258419

upstream raw materials:

N-(tert-butoxycarbonyl)glycine methyl ester

acrylic acid methyl ester

Downstream raw materials:

N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

3-allyl-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 194924-95-3 1,3-Pyrrolidinedicarboxylic acid, 4-oxo-, 1-(1,1-diMethylethyl) 3-Methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send