N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

Base Information

Chemical Name:N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide
CAS No.:1309676-07-0
Molecular Formula:C₂₀H₃₅N₃O₅
Molecular Weight:397.515
Hs Code.:

Synonyms:N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

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Technology Process of N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

There total 2 articles about N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 56414-87-0
(2S)-2-amino-N,N-diethyl-3-methylbutanamide

: 194924-95-3
4-oxopyrrolidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester

: 1309676-07-0
N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

Guidance literature:: With hydrogenchloride; In water; toluene; at 60 ℃; for 16h; Molecular sieve; Inert atmosphere;
DOI:10.1055/s-0030-1258419

Reference yield:

: 31954-27-5
N-(tert-butoxycarbonyl)glycine methyl ester

: 1309676-07-0
N-(1-tert-butyloxycarbonyl-3-methoxycarbonyl-2,5-dihydropyrrol-4-yl)-L-valine diethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 16 h / 23 °C / Inert atmosphere; Cooling with ice

2: hydrogenchloride / water; toluene / 16 h / 60 °C / Molecular sieve; Inert atmosphere

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; toluene;
DOI:10.1055/s-0030-1258419