6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)-

Base Information

Chemical Name:6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)-
CAS No.:194935-03-0
Molecular Formula:C28H34FNO4
Molecular Weight:467.581
Hs Code.:
Mol file:194935-03-0.mol

Synonyms:

Suppliers and Price of 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)-

There total 5 articles about 6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, 1,1-dimethylethyl ester, (3S,5R,6E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 194935-02-9
((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3-hydroxy-5-oxo-6-heptenoic acid 1,1-dimethylethyl ester

: 194935-03-0,129332-29-2
S-((R*S*)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 3h;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 194935-03-0,129332-29-2
S-((R*S*)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: tetramethylammonium triacetoxyborohydride, acetic acid / acetonitrile / 2 h / -10 °C

3: DDQ / tetrahydrofuran / Ambient temperature

4: 82 percent / NaBH₄, Et₂BOMe / tetrahydrofuran; methanol / 3 h / -78 °C

With sodium tetrahydroborate; diethyl methoxy borane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 93957-50-7
3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal

: 194935-03-0,129332-29-2
S-((R*S*)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: tetramethylammonium triacetoxyborohydride, acetic acid / acetonitrile / 2 h / -10 °C

3: DDQ / tetrahydrofuran / Ambient temperature

4: 82 percent / NaBH₄, Et₂BOMe / tetrahydrofuran; methanol / 3 h / -78 °C

With sodium tetrahydroborate; diethyl methoxy borane; acetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(97)00686-8