tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate

Base Information

Chemical Name:tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate
CAS No.:194934-95-7
Molecular Formula:C₂₈H₃₂FNO₄
Molecular Weight:465.565
Hs Code.:
Mol file:194934-95-7.mol

Synonyms:6-Heptenoicacid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-,1,1-dimethylethyl ester, [S-(E)]-;tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate;

Suppliers and Price of tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
O-tert-Butyl-3-ketoFluvastatin
10mg
$ 1055.00

Crysdot
(S,E)-tert-Butyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoate 95+%
1g
$ 2257.00

Crysdot
(S,E)-tert-Butyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoate 95+%
100mg
$ 563.00

Crysdot
(S,E)-tert-Butyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoate 95+%
250mg
$ 902.00

Chemenu
(S,E)-tert-Butyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoate 95%
250mg
$ 851.00

BLDpharm
(S,E)-tert-Butyl7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxohept-6-enoate 95+%
1g
$ 1824.00

American Custom Chemicals Corporation
TERT-BUTYL-(E)-7-[3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL]-5-HYDROXY-3-OXO-6-HEPTENOATE 95.00%
5MG
$ 496.83

Total 41 raw suppliers

Chemical Property of tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate

Chemical Property:

Vapor Pressure:1.16E-17mmHg at 25°C
Refractive Index:1.552
Boiling Point:647.7 °C at 760 mmHg
Flash Point:345.5 °C
PSA：68.53000
Density:1.13 g/cm³
LogP:6.09340
Storage Temp.:2-8°C

Purity/Quality:

97% ^*data from raw suppliers

O-tert-Butyl-3-ketoFluvastatin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses O-tert-Butyl-3-keto Fluvastatin is a reactant in the synthesis of Fluvastatin Sodium Salt (F601250), a synthetic HMG-CoA reductase inhibitor. Antilipemic.

Technology Process of tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate

There total 1 articles about tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 95061-51-1
(S)-2-acetoxy-1,1,2-triphenylethanol

: 93957-50-7
3-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-2(E)-propenal

: 108998-83-0
(S)-1,1,2-triphenyl-1,2-ethanediol

: 194934-95-7
((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 194934-95-7
((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester

: 194935-00-7,129332-29-2
(S-(R*R*)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid 1,1-dimethylethyl ester

Guidance literature:: With acetic acid; tetramethylammonium triacetoxyborohydride; In acetonitrile; at -10 ℃; for 2h;
DOI:10.1016/S0040-4020(97)00686-8

Reference yield:

: 194934-95-7
((S)-(E))-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoic acid 1,1-dimethylethyl ester

: -7-<3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl>-3,5-dihydroxy-6-heptenoic acid, sodium salt

Guidance literature:: Multi-step reaction with 2 steps

1: tetramethylammonium triacetoxyborohydride, acetic acid / acetonitrile / 2 h / -10 °C

2: aq. NaOH / ethanol / 1.58 h / 25 °C

With sodium hydroxide; acetic acid; tetramethylammonium triacetoxyborohydride; In ethanol; acetonitrile;
DOI:10.1016/S0040-4020(97)00686-8