1-BENZO[1,3]DIOXOL-5-YL-ETHYLAMINE

Base Information

• Chemical Name: 1-BENZO[1,3]DIOXOL-5-YL-ETHYLAMINE
• CAS No.: 121734-64-3
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Hs Code.: 2932999099
• Mol file: 121734-64-3.mol

Synonyms:1-(Benzo[d][1,3]dioxol-5-yl)ethanamine;1-(1,3-Benzodioxol-5-yl)ethanamine;

Chemical Property of 1-BENZO[1,3]DIOXOL-5-YL-ETHYLAMINE

Chemical Property:

• Vapor Pressure: 0.0119mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 260.9 °C at 760 mmHg
• Flash Point: 120.6 °C
• PSA: 44.48000
• Density: 1.198 g/cm³
• LogP: 2.13530

Purity/Quality:

98%Min ^*data from raw suppliers

1-(1,3-Benzodioxol-5-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZO[1,3]DIOXOL-5-YL-ETHYLAMINE

There total 6 articles about 1-BENZO[1,3]DIOXOL-5-YL-ETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(benzo[d][1,3]dioxol-5-yl)ethan-1-one oxime (62681-68-9) → 1-benzo[1,3]dioxol-5-yl-ethylamine (121734-64-3)

Guidance literature:

With ammonium hydroxide; hydrogen; nickel; In methanol;

DOI:10.1016/j.bmcl.2004.06.035

Reference yield: 95.0%

1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) → 1-benzo[1,3]dioxol-5-yl-ethylamine (121734-64-3)

Guidance literature:

1-(benzo[d][1,3]dioxol-6-yl)ethanone; With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; 1,2-bis-(diphenylphosphino)ethane; In dodecane; toluene; at -5 ℃; for 0.5h; under 4500.45 Torr; Autoclave;

With hydrogen; In dodecane; toluene; at 140 ℃; for 16h; under 30003 Torr; chemoselective reaction; Acidic conditions;

DOI:10.1002/adsc.201500968

Reference yield: 95.0%

→ 1-benzo[1,3]dioxol-5-yl-ethylamine (121734-64-3)

Guidance literature:

With aluminium(III) triflate; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); ammonia; hydrogen; 1,2-bis-(diphenylphosphino)ethane; at 140 ℃; for 16h; Autoclave;

upstream raw materials:

1-(benzo[d][1,3]dioxol-5-yl)ethan-1-one oxime

1-(benzo[d][1,3]dioxol-6-yl)ethanone

1-benzo[1,3]dioxol-5-yl-ethanol

Downstream raw materials:

1-(benzo[d][1,3]dioxol-6-yl)ethanone

2-[4-(1-benzo[1,3]dioxol-5-yl-ethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-5-methyl-benzonitrile

(+/-)-N-(1-benzo[1,3]dioxol-5-ylethyl)-3-(2-chlorophenyl)acrylamide

Refernces

• 1、 Beller, Matthias,Chandrashekhar, Vishwas G.,Jagadeesh, Rajenahally V.,Jiao, Haijun,Murugesan, Kathiravan,Wei, Zhihong. "General and selective synthesis of primary amines using Ni-based homogeneous catalysts". . p. 4332 - 4339. Retrieved 2020/05/18.
• 2、 Cui, Zhibing,Liu, Jianguo,Liu, Qiying,Ma, Longlong,Singh, Thishana,Wang, Chenguang,Wang, Nan,Zhu, Yuting. "Facile synthesis of controllable graphene-co-shelled reusable Ni/NiO nanoparticles and their application in the synthesis of amines under mild conditions". supporting information. p. 7387 - 7397. Retrieved 2020/11/19.