2H-Indol-2-one, 4,6-dibromo-1,3-dihydro-3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-meth yl-

Base Information

Chemical Name:2H-Indol-2-one, 4,6-dibromo-1,3-dihydro-3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-meth yl-
CAS No.:195134-85-1
Molecular Formula:C17H15Br2NO3
Molecular Weight:441.119
Hs Code.:

Synonyms:

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Chemical Property of 2H-Indol-2-one, 4,6-dibromo-1,3-dihydro-3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-meth yl-

Chemical Property:

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Technology Process of 2H-Indol-2-one, 4,6-dibromo-1,3-dihydro-3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-meth yl-

There total 8 articles about 2H-Indol-2-one, 4,6-dibromo-1,3-dihydro-3-hydroxy-1-[(4-methoxyphenyl)methyl]-3-meth yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 195134-84-0
4,6-Dibromo-1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester

: 195134-85-1
4,6-dibromo-3-hydroxy-1-(4-methoxybenzyl)-3-methylindolin-2-one

Guidance literature:: With sodium hydroxide; air; In tetrahydrofuran; for 21h; Heating;
DOI:10.1039/a700683g

Reference yield:

: 618-58-6
3,5-dibromobenzoic acid

: 195134-85-1
4,6-dibromo-3-hydroxy-1-(4-methoxybenzyl)-3-methylindolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / diphenylphosphoryl azide, NEt₃ / 18 h / Heating

2: 100 percent / NaH / dimethylformamide / 1.) 20 min, 2.) 21 h

3: TFA / CH₂Cl₂ / 1.33 h / Ambient temperature

4: 66 percent / NEt₃ / CH₂Cl₂ / 70 h / Ambient temperature

5: 99 percent / Rh₂(NHCOC₃F₇)4 / CH₂Cl₂ / 1.5 h / Ambient temperature

6: 66 percent / NaH / dimethylformamide / 1.) ice-cooling, 0.5 h, 2.) ice-cooling to r.t., 3 h

7: 99 percent / aq. NaOH, air / tetrahydrofuran / 21 h / Heating

With sodium hydroxide; air; diphenylphosphoranyl azide; sodium hydride; triethylamine; trifluoroacetic acid; Rh₂(NHCOC₃F₇)4; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a700683g

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 195134-85-1
4,6-dibromo-3-hydroxy-1-(4-methoxybenzyl)-3-methylindolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / NaH / dimethylformamide / 1.) 20 min, 2.) 21 h

2: TFA / CH₂Cl₂ / 1.33 h / Ambient temperature

3: 66 percent / NEt₃ / CH₂Cl₂ / 70 h / Ambient temperature

4: 99 percent / Rh₂(NHCOC₃F₇)4 / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 66 percent / NaH / dimethylformamide / 1.) ice-cooling, 0.5 h, 2.) ice-cooling to r.t., 3 h

6: 99 percent / aq. NaOH, air / tetrahydrofuran / 21 h / Heating

With sodium hydroxide; air; sodium hydride; triethylamine; trifluoroacetic acid; Rh₂(NHCOC₃F₇)4; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a700683g