Technology Process of 4,6-dibromo-1-(4-methoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl acetate
There total 9 articles about 4,6-dibromo-1-(4-methoxybenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
for 25h;
Ambient temperature;
DOI:10.1039/a700683g
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 82 percent / diphenylphosphoryl azide, NEt3 / 18 h / Heating
2: 100 percent / NaH / dimethylformamide / 1.) 20 min, 2.) 21 h
3: TFA / CH2Cl2 / 1.33 h / Ambient temperature
4: 66 percent / NEt3 / CH2Cl2 / 70 h / Ambient temperature
5: 99 percent / Rh2(NHCOC3F7)4 / CH2Cl2 / 1.5 h / Ambient temperature
6: 66 percent / NaH / dimethylformamide / 1.) ice-cooling, 0.5 h, 2.) ice-cooling to r.t., 3 h
7: 99 percent / aq. NaOH, air / tetrahydrofuran / 21 h / Heating
8: 99 percent / NEt3, DMAP / CH2Cl2 / 25 h / Ambient temperature
With
dmap; sodium hydroxide; air; diphenylphosphoranyl azide; sodium hydride; triethylamine; trifluoroacetic acid;
Rh2(NHCOC3F7)4;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a700683g
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / NaH / dimethylformamide / 1.) 20 min, 2.) 21 h
2: TFA / CH2Cl2 / 1.33 h / Ambient temperature
3: 66 percent / NEt3 / CH2Cl2 / 70 h / Ambient temperature
4: 99 percent / Rh2(NHCOC3F7)4 / CH2Cl2 / 1.5 h / Ambient temperature
5: 66 percent / NaH / dimethylformamide / 1.) ice-cooling, 0.5 h, 2.) ice-cooling to r.t., 3 h
6: 99 percent / aq. NaOH, air / tetrahydrofuran / 21 h / Heating
7: 99 percent / NEt3, DMAP / CH2Cl2 / 25 h / Ambient temperature
With
dmap; sodium hydroxide; air; sodium hydride; triethylamine; trifluoroacetic acid;
Rh2(NHCOC3F7)4;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/a700683g
