(2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol

Base Information

• Chemical Name: (2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol
• CAS No.: 75291-50-8
• Molecular Formula: C11H16N3O3+
• Molecular Weight: 237.258
• DSSTox Substance ID: DTXSID00503167
• NSC Number: 111083
• Mol file: 75291-50-8.mol

Synonyms:75291-50-8;(2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol;DTXSID00503167;NSC111083;NSC-111083;2-(Cyclohexylamino)-4-nitropyridine 1-oxide;N-cyclohexyl-1-hydroxy-4-nitropyridin-2-imine

Chemical Property of (2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 237.11134135
• Heavy Atom Count: 17
• Complexity: 389

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCC(CC1)N=C2C=C(C=CN2O)[N+](=O)[O-]

Technology Process of (2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol

There total 2 articles about (2E)-2-(Cyclohexylimino)-4-nitropyridin-1(2H)-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-chloro-4-nitropyridine-N-oxide (14432-16-7) + cyclohexylamine (108-91-8,157973-60-9) → cyclohexyl-(4-nitro-1-oxy-pyridin-2-yl)-amine (75291-50-8)

Guidance literature:

In ethanol; at 80 ℃; for 13h;

DOI:10.1016/j.bmc.2013.02.021

Reference yield: 69.0%

2-bromo-4-nitropyridine N-oxide (52092-43-0) + cyclohexylamine (108-91-8,157973-60-9) → cyclohexyl-(4-nitro-1-oxy-pyridin-2-yl)-amine (75291-50-8)

Guidance literature:

In ethanol; at 70 - 80 ℃; for 3h;

Reference yield: 52.0%

cyclohexyl-(4-nitro-1-oxy-pyridin-2-yl)-amine (75291-50-8) + acetyl chloride (75-36-5) → N-(4-Chloro-1-oxy-pyridin-2-yl)-N-cyclohexyl-acetamide (75291-53-1)

Guidance literature:

for 2h; Heating;

upstream raw materials:

2-bromo-4-nitropyridine N-oxide

cyclohexylamine

2-chloro-4-nitropyridine-N-oxide

Downstream raw materials:

N-(4-Chloro-1-oxy-pyridin-2-yl)-N-cyclohexyl-acetamide

2-cyclohexylamino-4-chloropyridine

Cyclohexyl-(4-morpholin-4-yl-pyridin-2-yl)-amine

Cyclohexyl-(4-morpholin-4-yl-1-oxy-pyridin-2-yl)-amine