ethyl-5-chloro-2-[(ethoxycarbonyl) oxy]-1H-indole-1-carboxylate

Base Information

• Chemical Name: ethyl-5-chloro-2-[(ethoxycarbonyl) oxy]-1H-indole-1-carboxylate
• CAS No.: 197775-85-2
• Molecular Formula: C14H14ClNO5
• Molecular Weight: 311.71800
• Mol file: 197775-85-2.mol

Synonyms:ethyl-5-chloro-2-[(ethoxycarbonyl)oxy]-1H-indole-1-carboxylate;

Chemical Property of ethyl-5-chloro-2-[(ethoxycarbonyl) oxy]-1H-indole-1-carboxylate

Chemical Property:

• PSA: 66.76000
• LogP: 3.83460

Purity/Quality:

5-Chloro-2-[(ethoxycarbonyl)oxy]-1H-indole-1-carboxylicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloro-2-[(ethoxycarbonyl)oxy]-1H-indole-1-carboxylic Acid Ethyl Ester is an intermediate used in synthesizing 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic Acid Ethyl Ester, which is synthesized from 5-chloro-2-oxindole (C375030), that is used in the preparation of novel GSK-3β inhibitors as anticancer agents.

Technology Process of ethyl-5-chloro-2-[(ethoxycarbonyl) oxy]-1H-indole-1-carboxylate

There total 2 articles about ethyl-5-chloro-2-[(ethoxycarbonyl) oxy]-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 5-chloro-1-ethoxycarbonyl-2-(ethoxycarbonyloxy)indole (197775-85-2)

Guidance literature:

Reference yield: 94.0%

5-chloro-indolin-2-one (17630-75-0) + chloroformic acid ethyl ester (541-41-3) → 5-chloro-1-ethoxycarbonyl-2-(ethoxycarbonyloxy)indole (197775-85-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00477-4

Reference yield: 89.0%

5-chloro-1-ethoxycarbonyl-2-(ethoxycarbonyloxy)indole (197775-85-2) → 5-chloro-1-ethoxycarbonyl-2-oxo-2,3-dihydroindole (197776-07-1)

Guidance literature:

With ammonium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/S0040-4020(00)00477-4

upstream raw materials:

5-chloro-indolin-2-one

chloroformic acid ethyl ester

Downstream raw materials:

5-chloro-1-ethoxycarbonyl-2-oxo-2,3-dihydroindole

5-chloro-2-phenoxycarbonyloxy-indole-1-carboxylic acid ethyl ester

2-benzyloxycarbonyloxy-5-chloro-indole-1-carboxylic acid ethyl ester

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