O-ACETYLSALICYLHYDROXAMIC ACID

Base Information

• Chemical Name: O-ACETYLSALICYLHYDROXAMIC ACID
• CAS No.: 199854-00-7
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Mol file: 199854-00-7.mol

Synonyms:N-(Acetyloxy)-2-hydroxybenzamide;

Chemical Property of O-ACETYLSALICYLHYDROXAMIC ACID

Chemical Property:

• Refractive Index: 1.563
• PSA: 75.63000
• Density: 1.316 g/cm³
• LogP: 0.99100
• Solubility.: ≤25mg/ml in ethanol;50mg/ml in DMSO;30mg/ml in dimethyl formamide

Purity/Quality:

98%Min ^*data from raw suppliers

O-Acetylsalicylhydroxamic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An irreversible, non-selective inhibitor of COX-1 and COX-2.

Technology Process of O-ACETYLSALICYLHYDROXAMIC ACID

There total 5 articles about O-ACETYLSALICYLHYDROXAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

salicylhydroxamic acid (89-73-6) + acetyl chloride (75-36-5) → O-acetylsalicylhydroxamic acid (199854-00-7)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1177/1747519820907563

Reference yield:

4-nitrophenol acetate (830-03-5) + salicylhydroxamate → O-acetylsalicylhydroxamic acid (199854-00-7) + p-nitrophenolate (14609-74-6)

Guidance literature:

With potassium chloride; cetyltrimethylammonim bromide; In phosphate buffer; acetonitrile; at 27 ℃; pH=7.7; Further Variations:; Reagents; Kinetics;

DOI:10.1002/kin.20117

Reference yield:

salicylhydroxamic acid (89-73-6) + 4-nitrophenol acetate (830-03-5) → O-acetylsalicylhydroxamic acid (199854-00-7) + p-nitrophenolate (14609-74-6)

Guidance literature:

With phosphate buffer; potassium chloride; cetyltrimethylammonim bromide; In water; at 27 ℃; pH=7.7; Further Variations:; Reagents; pH-values; Kinetics;

upstream raw materials:

salicylhydroxamic acid

acetic anhydride

4-nitrophenol acetate

acetyl chloride

Downstream raw materials:

Zn(O-acetylsalicylhydroxamate)

Zn(O-acetylsalicylhydroxamate) * H₂O

2-Benzoxazolinone

acetic acid

Refernces

• 1、 Ghosh, Kallol K.,Vaidya, Jyoti,Satnami, Manmohan Lal. "The α-effect in micelles: Nucleophilic substitution reaction of p-nitrophenyl acetate with N-phenylbenzohydroxamate ion". . p. 26 - 31. Retrieved 2008/02/09.