1-Piperidinecarboxylic acid, 4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl] -1H-imidazol-2-yl]-, phenylmethyl ester

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl] -1H-imidazol-2-yl]-, phenylmethyl ester
CAS No.:200801-90-7
Molecular Formula:C28H26F3N5O3S
Molecular Weight:569.607
Hs Code.:

1-Piperidinecarboxylic acid,
4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl]
-1H-imidazol-2-yl]-, phenylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Piperidinecarboxylic acid, 4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl] -1H-imidazol-2-yl]-, phenylmethyl ester

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Technology Process of 1-Piperidinecarboxylic acid, 4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl] -1H-imidazol-2-yl]-, phenylmethyl ester

There total 6 articles about 1-Piperidinecarboxylic acid, 4-[1-hydroxy-5-[2-(methylthio)-4-pyrimidinyl]-4-[3-(trifluoromethyl)phenyl] -1H-imidazol-2-yl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 200801-89-4
1-<2-(methylthio)pyrimidin-4-yl>-2-<3-(trifluoromethyl)phenyl>ethane-1,2-dione 1-oxime

: 200801-90-7
4-[1-hydroxy-5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester

Guidance literature:: With ammonium acetate; acetic acid; for 2h; Heating;
DOI:10.1021/jm9805236

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 200801-90-7
4-[1-hydroxy-5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0.5 h / 5 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

3: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

4: 97 percent / ammonium acetate, AcOH / 2 h / Heating

With ammonium acetate; acetic acid; triethylamine; lithium diisopropyl amide; sodium nitrite; In dichloromethane;
DOI:10.1021/jm9805236

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 200801-90-7
4-[1-hydroxy-5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

2: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

3: 97 percent / ammonium acetate, AcOH / 2 h / Heating

With ammonium acetate; acetic acid; lithium diisopropyl amide; sodium nitrite;
DOI:10.1021/jm9805236