(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

Base Information

Chemical Name:(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine
CAS No.:200801-84-9
Molecular Formula:C₂₈H₂₉F₃N₆
Molecular Weight:506.574
Hs Code.:

Synonyms:(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

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Technology Process of (S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

There total 12 articles about (S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 200801-99-6
(S)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole

: 200801-84-9
(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In isopropyl alcohol; for 24h; under 760 Torr;
DOI:10.1021/jm9805236

Reference yield:

: 144-55-8
sodium hydrogencarbonate

: 200801-99-6
(S)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole

: 200801-84-9
(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

Guidance literature:: With hydrogen bromide; In dichloromethane; acetic acid;

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 200801-84-9
(S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

2: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

3: 97 percent / ammonium acetate, AcOH / 2 h / Heating

4: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

5: 65 percent / toluene / 48 h / Heating

6: 95 percent / Oxone / methanol; H₂O / 4 h / 20 °C

7: 90 percent / 0.17 h / 140 °C

8: 88 percent / H₂ / 10 percent Pd/C / propan-2-ol / 24 h / 760 Torr

With ammonium acetate; hydrogenchloride; Oxone; titanium(III) chloride; hydrogen; acetic acid; lithium diisopropyl amide; sodium nitrite; palladium on activated charcoal; In methanol; water; isopropyl alcohol; toluene;
DOI:10.1021/jm9805236