200801-89-4

Upstream product

• 116332-62-8 N-methoxy-N-methyl-3-trifluoromethylbenzamide 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 
• 14001-63-9 2-methylthio-4-methylpyrimidine 
• 200801-88-3 2-(2-Methylsulfanylpyrimidin-4-yl)-1-(3-trifluoromethylphenyl)ethanone 

Downstream Products

• 271247-53-1 2-(2-methylthiopyrimidin-4-yl)-3-(3-trifluoromethylphenyl)pyrazine 
• 200801-93-0 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-27-0 (S)-4-[5-[2-(1-phenylethylamino)-pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-25-8 (R)-4-[5-(2-(1-phenylethylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-99-6 (S)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 
• 234767-12-5 (R)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 
• 200801-92-9 5-<2-(methylsulfonyl)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 234767-11-4 4-[4-(2-methanesulfonyl-pyrimidin-4-yl)-1-methyl-5-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-95-2 5-<2-(methylsulfonyl)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 200801-20-3 4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine 
• 200801-91-8 5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 219646-44-3 4-[4-(2-methylthiopyrimidin-4-yl)-1-methyl-5-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-94-1 5-<2-(methylthio)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 200801-84-9 (S)-{4-[3-methyl-2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-(1-phenylethyl)amine 

Relevant academic research and scientific papers

SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY

Compounds represented by formula I: I are disclosed. AR represents an aromatic group containing 6-10 atoms; and represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional

Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays of tumor necrosis factor-α (TNF-α) release and an animal model of rheumatoid arthritis. The SAR