4-Pyridineethanol, a-phenyl-

Base Information

• Chemical Name: 4-Pyridineethanol, a-phenyl-
• CAS No.: 20151-37-5
• Molecular Formula: C13H13NO
• Molecular Weight: 199.252
• Mol file: 20151-37-5.mol

Synonyms:

Chemical Property of 4-Pyridineethanol, a-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pyridineethanol, a-phenyl-

There total 9 articles about 4-Pyridineethanol, a-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-[(trimethylsilanyl)methyl]-pyridine (6844-47-9) + benzaldehyde (100-52-7) → picoline (108-89-4) + rac-1-phenyl-2-(4-pyridyl)ethanol (20151-37-5)

Guidance literature:

With hydrogenchloride; potassium fluoride; 18-crown-6 or silica-supported tetrabutylammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h; Yields of byproduct given;

DOI:10.1016/S0040-4039(00)86894-X

Reference yield: 78.0%

4-picoline boron trifluoride complex + benzaldehyde (100-52-7) → (4-methylpyridin-2-yl)-3-phenylmethanol (82226-09-3) + rac-1-phenyl-2-(4-pyridyl)ethanol (20151-37-5)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; at -78 ℃; for 1h; Further Variations:; Reagents; Solvents; Product distribution;

DOI:10.3987/COM-04-10229

Reference yield: 75.0%

trans-4-(3-phenyloxiran-2-yl)pyridine → rac-1-phenyl-2-(4-pyridyl)ethanol (20151-37-5)

Guidance literature:

With sodium tetrahydroborate; palladium 10% on activated carbon; In methanol; water; at 20 ℃; for 4h; regioselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.200800992

upstream raw materials:

picoline

benzaldehyde

4-[(trimethylsilanyl)methyl]-pyridine

4-(Chloromethyl)pyridine

Downstream raw materials:

picoline

trans-4-styrylpyride

benzaldehyde

Refernces

• 1、 Barrios-Rivera, Jonathan,Xu, Yingjian,Clarkson, Guy J.,Wills, Martin. "Asymmetric transfer hydrogenation of heterocycle-containing acetophenone derivatives using N-functionalised [(benzene)Ru(II)(TsDPEN)] complexes". . . Retrieved 2021/12/02.
• 2、 Lewis, Jared D.,Moore, John N.. "Cation sensors containing a (bpy)Re(CO)3 group linked to an azacrown ether via an alkenyl or alkynyl spacer: Synthesis, characterisation, and complexation with metal cations in solution". . p. 1376 - 1385. Retrieved 2007/10/03.