1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

Base Information

Chemical Name:1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid
CAS No.:203869-80-1
Molecular Formula:C11H19NO4
Molecular Weight:229.276
Hs Code.:2933990090
European Community (EC) Number:676-379-7
DSSTox Substance ID:DTXSID70400730
Mol file:203869-80-1.mol

Synonyms:203869-80-1;1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid;1-Boc-2-methyl-DL-proline;2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic Acid;Boc-alpha-Me-DL-Pro-OH;BOC-ALPHA-ALLYL-ME-DL-PRO-OH;MFCD03095494;2-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;1-Boc-2-methyl-2-pyrrolidinecarboxylic acid;N-Boc-2-methyl-D-proline;MFCD06797554;MFCD08706361;Boc- alpha -Me-DL-Pro-OH;SCHEMBL192363;boc-alpha-methyl-(d,l)-proline;DTXSID70400730;YQXRKJHVAUKXRN-UHFFFAOYSA-N;CS-M0708;VFA68101;AKOS004910715;AKOS015999984;AB13740;CCG-211609;AS-36881;PD197216;SY060256;SY097096;SY185453;1-BOC-2-methylpyrrolidine-2-carboxylic acid;FT-0735337;EN300-80865;Boc-alpha-Me-DL-Pro-OH, >=96.0% (HPLC);A848469;J-013271;Z1224475335;1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid

Suppliers and Price of 1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicAcid
500mg
$ 155.00

SynQuest Laboratories
1-Boc-2-methyl-2-pyrrolidinecarboxylic acid
5 g
$ 680.00

SynQuest Laboratories
1-Boc-2-methyl-2-pyrrolidinecarboxylic acid
1 g
$ 215.00

SynQuest Laboratories
1-Boc-2-methyl-2-pyrrolidinecarboxylic acid
250 mg
$ 104.00

Sigma-Aldrich
Boc-α-Me-DL-Pro-OH ≥96.0% (HPLC)
500mg
$ 231.00

Matrix Scientific
2-Methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester
250mg
$ 310.00

Crysdot
1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicacid 97%
5g
$ 880.00

Crysdot
1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicacid 97%
1g
$ 275.00

ChemScene
1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicacid
1g
$ 92.00

ChemScene
1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicacid
5g
$ 278.00

Total 32 raw suppliers

Chemical Property of 1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

Chemical Property:

Appearance/Colour:White to gray powder
Vapor Pressure:1.92E-05mmHg at 25°C
Melting Point:91-94 °C
Refractive Index:1.494
Boiling Point:337.8 °C at 760 mmHg
PKA:4.20±0.20(Predicted)
Flash Point:158.1 °C
PSA：66.84000
Density:1.16 g/cm³
LogP:1.79850
Storage Temp.:2-8°C
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:229.13140809
Heavy Atom Count:16
Complexity:308

Purity/Quality:

97% ^*data from raw suppliers

1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1(CCCN1C(=O)OC(C)(C)C)C(=O)O

Technology Process of 1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid

There total 5 articles about 1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 317355-80-9,1358783-73-9
2-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 203869-80-1
1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: 2-methyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester; With sodium hydroxide; In methanol; water; for 5h; Reflux;

With hydrogenchloride; In water; pH=3;
DOI:10.1016/j.tet.2010.03.002

Reference yield:

: 145681-01-2
(+/-)-N-tert-butoxycarbonylproline methyl ester

: 203869-80-1
1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / water; methanol / 1 h / 80 °C / Inert atmosphere

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;
DOI:10.1002/chem.202001123

Reference yield:

: 609-36-9,25191-13-3,37159-97-0,4305-67-3,4607-28-7
rac-Pro-OH

: 203869-80-1
1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 1 h / 0 °C / Inert atmosphere; Reflux

2.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere

3.2: 18 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / water; methanol / 1 h / 80 °C / Inert atmosphere

With thionyl chloride; triethylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1002/chem.202001123