8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Base Information

• Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine
• CAS No.: 205584-61-8
• Molecular Formula: C10H12BrN
• Molecular Weight: 262.57400
• Hs Code.: 2933990090
• ChEMBL ID: CHEMBL5019505
• DSSTox Substance ID: DTXSID60585707
• Wikidata: Q82477696
• Mol file: 205584-61-8.mol

Synonyms:205584-61-8;8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine;8-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine;1H-1-Benzazepine, 8-bromo-2,3,4,5-tetrahydro-;8-bromo-2,3,4,5-tetrahydro-1h-benzo[b]azepine hydrochloride;8-bromotetrahydrobenzazepine;SCHEMBL1246501;CHEMBL5019505;DTXSID60585707;BVWMQZXXXWEDOY-UHFFFAOYSA-N;MFCD09026499;AKOS022176951;DS-6540;CS-0155247;C73896;EN300-381027;A879557;8-bromo-2,3,4,5-tetrahydro-1h-benzo[b]azepinehydrochloride;8-Bromo-2 pound not3 pound not4 pound not5-tetrahydro-1H-benzo[b]azepine

Chemical Property of 8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Chemical Property:

• PSA: 12.03000
• LogP: 4.13730
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 225.01531
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99%, ^*data from raw suppliers

8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC2=C(C1)C=CC(=C2)Br

Technology Process of 8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

There total 3 articles about 8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

8-bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (885953-12-8) → 8-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (205584-61-8)

Guidance literature:

8-bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one; With borane-THF; In tetrahydrofuran; for 2h; Heating / reflux;

With ethanol; sulfuric acid; water; for 2h; Heating / reflux;

With sodium hydroxide; In ethanol; water; pH=10;

Reference yield: 68.0%

7-bromo-N-hydroxy-3,4-dihydronaphthalen-1(2H)-imine (877263-91-7) → 8-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (205584-61-8)

Guidance literature:

7-bromo-N-hydroxy-3,4-dihydronaphthalen-1(2H)-imine; With diisobutylaluminium hydride; In hexane; dichloromethane; at 0 - 20 ℃; for 2h;

With sodium fluoride; In hexane; dichloromethane; water; at 0 - 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2021.113383

Reference yield:

7-bromo-3,4-dihydro-2H-naphthalen-1-one (32281-97-3) → 8-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (205584-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; pyridine / 3 h / 20 °C

2.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / 0 - 20 °C

2.2: 2 h / 0 - 20 °C

With pyridine; hydroxylamine hydrochloride; diisobutylaluminium hydride; In hexane; dichloromethane;

DOI:10.1016/j.ejmech.2021.113383

upstream raw materials:

8-bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

7-bromo-3,4-dihydro-2H-naphthalen-1-one

7-bromo-N-hydroxy-3,4-dihydronaphthalen-1(2H)-imine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 205584-61-8 8-BROMO-2,3,4,5-TETRAHYDRO-1H-BENZO[B]AZEPINE HYDROCHLORIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send