1-(2,2-Dibromoethenyl)-3,5-dimethoxybenzene

Base Information

• Chemical Name: 1-(2,2-Dibromoethenyl)-3,5-dimethoxybenzene
• CAS No.: 205746-51-6
• Molecular Formula: C10H10Br2O2
• Molecular Weight: 321.996
• DSSTox Substance ID: DTXSID80441891
• Mol file: 205746-51-6.mol

Synonyms:1-(2,2-dibromoethenyl)-3,5-dimethoxybenzene;205746-51-6;SCHEMBL12814340;DTXSID80441891;1-(2,2-dibromo-vinyl)-3,5-dimethoxy-benzene

Chemical Property of 1-(2,2-Dibromoethenyl)-3,5-dimethoxybenzene

Chemical Property:

• PSA: 18.46000
• LogP: 3.79200
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 321.90271
• Heavy Atom Count: 14
• Complexity: 190

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)C=C(Br)Br)OC

Technology Process of 1-(2,2-Dibromoethenyl)-3,5-dimethoxybenzene

There total 1 articles about 1-(2,2-Dibromoethenyl)-3,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon tetrabromide (558-13-4) + 3,5-dimethoxybenzaldehdye (7311-34-4) → 3,5-dimethoxy-β,β-dibromostyrene (205746-51-6)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02403

Reference yield: 94.0%

3,5-dimethoxy-β,β-dibromostyrene (205746-51-6) → 1-Ethynyl-3,5-dimethoxy-benzene (171290-52-1)

Guidance literature:

With n-butyllithium; for 10h;

DOI:10.1016/j.tetlet.2009.02.067

Reference yield: 94.0%

chloroformic acid ethyl ester (541-41-3) + 3,5-dimethoxy-β,β-dibromostyrene (205746-51-6) → ethyl 3-(3,5-dimethoxyphenyl)propiolate (29577-38-6)

Guidance literature:

3,5-dimethoxy-β,β-dibromostyrene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

chloroformic acid ethyl ester; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.202005427

upstream raw materials:

carbon tetrabromide

3,5-dimethoxybenzaldehdye

Downstream raw materials:

[(3,5-dimethoxyphenyl)ethynyl]triisopropylsilane

1-(3,5-dihydroxyphenyl)-1-heptyne

1-Ethynyl-3,5-dimethoxy-benzene

(E)-1-(2-bromovinyl)-3,5-dimethoxybenzene