Methyl cyclohexylphenylglycolate, (-)-

Base Information

Chemical Name:Methyl cyclohexylphenylglycolate, (-)-
CAS No.:20585-38-0
Molecular Formula:C15H20O3
Molecular Weight:248.322
Hs Code.:
UNII:E36W62G1T1
Nikkaji Number:J58.822I
Wikidata:Q27276817

Synonyms:UNII-E36W62G1T1;Methyl cyclohexylphenylglycolate, (-)-;E36W62G1T1;20585-38-0;Cyclohexaneglycolic acid, alpha-phenyl-, methyl ester, (R)-(-)-;Benzeneacetic acid, alpha-cyclohexyl-alpha-hydroxy-, methyl ester, (alphaR)-;SCHEMBL4741114;SPTZOODMHSABLY-HNNXBMFYSA-N;(-)-methyl cyclohexylphenylglycolate;Q27276817;Methyl (R)-alpha-cyclohexyl-alpha-hydroxybenzeneacetate;(2R)-2-Hydroxy-2-cyclohexyl-2-phenylacetic acid methyl ester;CYCLOHEXANEGLYCOLIC ACID, .ALPHA.-PHENYL-, METHYL ESTER, (R)-(-)-;BENZENEACETIC ACID, .ALPHA.-CYCLOHEXYL-.ALPHA.-HYDROXY-, METHYL ESTER, (.ALPHA.R)-

Suppliers and Price of Methyl cyclohexylphenylglycolate, (-)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl cyclohexylphenylglycolate, (-)-

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:248.14124450
Heavy Atom Count:18
Complexity:278

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C(C1CCCCC1)(C2=CC=CC=C2)O
Isomeric SMILES:COC(=O)[C@@](C1CCCCC1)(C2=CC=CC=C2)O

Technology Process of Methyl cyclohexylphenylglycolate, (-)-

There total 8 articles about Methyl cyclohexylphenylglycolate, (-)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 20585-39-1
(2R)-2-Cyclohexyl-2-hydroxy-2-phenylacetic acid

: 20585-38-0
methyl (R)-α-cyclohexyl-α-hydroxybenzeneacetate

Guidance literature:: In diethyl ether;
DOI:10.1021/jm960374w

Reference yield: 92.0%

: 584-08-7
potassium carbonate

: 20585-39-1
(2R)-2-Cyclohexyl-2-hydroxy-2-phenylacetic acid

: 74-88-4
methyl iodide

: 20585-38-0
methyl (R)-α-cyclohexyl-α-hydroxybenzeneacetate

Guidance literature:: In acetone;

Reference yield:

: 611-71-2
(R)-Mandelic Acid

: 20585-38-0
methyl (R)-α-cyclohexyl-α-hydroxybenzeneacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / p-TsOH, conc. H₂SO₄ / pentane / Heating

2: 1.) LDA / 1.) THF, from -80 deg C to -15 deg C, 1 h, 2.) THF, from -80 deg C to -20 deg C, 2 h

3: 98 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3750.3 Torr

4: 85 percent / aq. KOH / methanol; diethyl ether

5: 98 percent / diethyl ether

With potassium hydroxide; sulfuric acid; hydrogen; toluene-4-sulfonic acid; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; pentane;
DOI:10.1021/jm960374w