L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester

Base Information

Chemical Name:L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester
CAS No.:209266-09-1
Molecular Formula:C17H29NO5SSi
Molecular Weight:387.572
Hs Code.:

Synonyms:

Suppliers and Price of L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester

Chemical Property:

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Technology Process of L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester

There total 6 articles about L-Serine, O-[(1,1-dimethylethyl)dimethylsilyl]-N-[(4-methylphenyl)sulfonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 17136-46-8
methyl (2S)-3-hydroxy-2-{[(4-methylphenyl)sulfonyl]amino}propanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 209266-09-1
methyl (S)-3-tret-butyldimethylsilyloxy-2-(4-methylphenylsulfamido)propanoate

Guidance literature:: DOI:10.1021/jo962307f

Reference yield: 83.0%

: 1492-24-6
L-2-aminobutyric acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 75-36-5
acetyl chloride

: 98-59-9
p-toluenesulfonyl chloride

: 209266-09-1
methyl (S)-3-tret-butyldimethylsilyloxy-2-(4-methylphenylsulfamido)propanoate

Guidance literature:: L-2-aminobutyric acid; acetyl chloride; In methanol; for 16h; Reflux;

p-toluenesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201500886

Reference yield: 76.0%

: 5874-57-7
R-(-)-serine methyl ester hydrochloride

: 18162-48-6
tert-butyldimethylsilyl chloride

: 98-59-9
p-toluenesulfonyl chloride

: 209266-09-1
methyl (S)-3-tret-butyldimethylsilyloxy-2-(4-methylphenylsulfamido)propanoate

Guidance literature:: R-(-)-serine methyl ester hydrochloride; p-toluenesulfonyl chloride; With triethylamine; In dichloromethane; chloroform; at 0 ℃; for 48h;

tert-butyldimethylsilyl chloride; With N,N-dimethyl-formamide; at 0 ℃; for 20h; Further stages.;
DOI:10.1021/ol0170152