8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione

Base Information

Chemical Name:8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione
CAS No.:21090-07-3
Molecular Formula:C21H29N3O2
Molecular Weight:355.48
Hs Code.:
ChEMBL ID:CHEMBL293968
DSSTox Substance ID:DTXSID70511193
Nikkaji Number:J2.405.720H
Pharos Ligand ID:CWTKB1CSKJSX
Wikidata:Q82369874
Mol file:21090-07-3.mol

Synonyms:CHEMBL293968;21090-07-3;8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione;DTXSID70511193;BDBM50026928;8-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-8-aza-spiro[4.5]decane-7,9-dione

Suppliers and Price of 8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:355.22597718
Heavy Atom Count:26
Complexity:495

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC2(C1)CC(=O)N(C(=O)C2)CCN3CCN(CC3)C4=CC=CC=C4

Technology Process of 8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione

There total 3 articles about 8-[2-(4-Phenylpiperazin-1-yl)ethyl]-8-azaspiro[4.5]decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 92-54-6
4-phenyl-1-piperazine

: 150758-78-4
8-(2-Bromoethyl)-8-azaspiro<4,5>decane-7,9-dione

: 21090-07-3
8-[2-(4-phenyl-piperazin-1-yl)-ethyl]-8-aza-spiro[4.5]decane-7,9-dione

Guidance literature:: With triethylamine; at 160 - 180 ℃; for 0.5h;
DOI:10.1021/jm030944+

Reference yield:

: 1075-89-4
tetramethylene glutarimide

: 21090-07-3
8-[2-(4-phenyl-piperazin-1-yl)-ethyl]-8-aza-spiro[4.5]decane-7,9-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / dimethylformamide

2: 98 percent / Et₃N / 0.5 h / 160 - 180 °C

With sodium hydride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm030944+