6,4'-DIBROMOFLAVONE

Base Information

• Chemical Name: 6,4'-DIBROMOFLAVONE
• CAS No.: 213894-81-6
• Molecular Formula: C15H8Br2O2
• Molecular Weight: 380.035
• Mol file: 213894-81-6.mol

Synonyms:6,4'-DIBROMOFLAVONE;

Chemical Property of 6,4'-DIBROMOFLAVONE

Chemical Property:

• Boiling Point: 458.0±45.0 °C(Predicted)
• PSA: 30.21000
• Density: 1.795±0.06 g/cm3(Predicted)
• LogP: 4.98500

Purity/Quality:

6,4'-DIBROMOFLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,4'-DIBROMOFLAVONE

There total 5 articles about 6,4'-DIBROMOFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(5-bromo-2-hydroxyphenyl)-3-(4-bromophenyl)-1,3-propanedione (849367-86-8) → 6,4'-Dibromoflavone (213894-81-6)

Guidance literature:

With sulfuric acid; at 20 ℃; for 1h;

Reference yield: 36.0%

6-bromo-4-oxo-4H-chromene-2-carboxylic acid (51484-06-1) + 4-Bromophenylboronic acid (5467-74-3) → 6,4'-Dibromoflavone (213894-81-6)

Guidance literature:

With dipotassium peroxodisulfate; In water; 1,2-dichloro-ethane; at 100 ℃; for 2h; regioselective reaction; Sealed tube; Green chemistry;

DOI:10.1039/c7cc02107k

Reference yield:

4-bromobenzoic acid 2'-acetyl-4'-bromophenyl ester (849367-85-7) → 6,4'-Dibromoflavone (213894-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 74.3 percent / KOH; pyridine / 1 h / 60 °C

2: 89.5 percent / sulfuric acid / 0.33 h / 20 °C

With pyridine; potassium hydroxide; sulfuric acid; 1: Baker-Venkataraman rearrangement;

DOI:10.1016/j.bmc.2004.12.006

upstream raw materials:

1-(5-bromo-2-hydroxyphenyl)-3-(4-bromophenyl)-1,3-propanedione

4-bromobenzoic acid 2'-acetyl-4'-bromophenyl ester

5-Bromo-2-hydroxyacetophenone

4-chlorobenzoyl chloride

Downstream raw materials:

6-cyano-2-(4-cyanophenyl)-4H-1-benzopyran-4-one