2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid

Base Information

• Chemical Name: 2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid
• CAS No.: 21472-50-4
• Molecular Formula: C13H16O3
• Molecular Weight: 220.26400
• Mol file: 21472-50-4.mol

Synonyms:2-Hydroxy-2-phenyl-cyclohexancarbonsaeure;2-Phenyl-2-hydroxy-cyclohexancarbonsaeure;2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid;

Chemical Property of 2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid

Chemical Property:

• Melting Point: 143 - 145 °C
• PSA: 57.53000
• LogP: 2.14900

Purity/Quality:

98% or more ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid

There total 10 articles about 2-Hydroxy-2-phenyl-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

carbon dioxide (124-38-9,18923-20-1) + 1-Phenylcyclohexene (771-98-2) + acetonitrile (75-05-8,26809-02-9) → cis-2-acetamido-2-phenylcyclohexanecarboxylic acid + 2-phenylcyclohex-2-ene-1-carboxylic acid (24102-01-0) + 3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylic acid (108299-04-3) + 2-hydroxy-2-phenyl-cyclohexanecarboxylic acid (21472-50-4)

Guidance literature:

carbon dioxide; 1-Phenylcyclohexene; acetonitrile; With N,N,N',N'-tetramethylbenzidine; at 10 ℃; for 10h; UV-irradiation;

In chloroform; at 20 ℃; for 120h;

DOI:10.1016/j.tet.2007.02.013

Reference yield:

→ cis-2-hydroxy-2-phenyl-r-1-cyclohexanecarboxylic acid (21472-50-4,37545-85-0,57808-63-6)

Guidance literature:

aus Chlorid (8), 1) wss. Ag2O, 2) Aceton/ H2O;

Reference yield:

→ 2t-Hydroxy-2c-phenylcyclohexan-1-carbonsaeure (21472-50-4,37545-85-0,57808-63-6)

Guidance literature:

Hydroxymethylcyclohexanol VIII , CrO3;

upstream raw materials:

2-Hydroxymethyl-1-phenyl-cyclohexanol

carbon dioxide

1-Phenylcyclohexene

acetonitrile

Downstream raw materials:

2-chloro-2-phenyl-cyclohexanecarboxylic acid

2-phenylcyclohex-2-ene-1-carboxylic acid

8-aza-8-methylbicyclo [3.2.1]oct-3-yl 2-phenylcyclohex-2-enecarboxylate

2-phenyl-2-cyclohexene-1-carbonyl chloride