3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-, dimethyl ester

Base Information

• Chemical Name: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-, dimethyl ester
• CAS No.: 216507-82-3
• Molecular Formula: C20H21F3N2O5
• Molecular Weight: 426.392
• Mol file: 216507-82-3.mol

Synonyms:

Chemical Property of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-, dimethyl ester

There total 3 articles about 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-Dihydro-2,6-dimethyl-4-[3-[(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid, dimethyl ester (115746-21-9) → 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid dimethyl ester (216507-82-3)

Guidance literature:

With NaH; In N,N-dimethyl-formamide;

Reference yield:

1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester (21835-63-2) → 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid dimethyl ester (216507-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

2: NaH / dimethylformamide / 1 h

With pyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2003.10.016

Reference yield:

1,4-Dihydro-2,6-dimethyl-4-[3-[(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid, dimethyl ester (115746-21-9) + methyl iodide (74-88-4) → 1,4-dihydro-2,6-dimethyl-4-[3-[methyl(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid dimethyl ester (216507-82-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1h;

DOI:10.1016/j.bmc.2003.10.016

upstream raw materials:

1,4-Dihydro-2,6-dimethyl-4-[3-[(trifluoroacetyl)amino]phenyl]-3,5-pyridinedicarboxylic acid, dimethyl ester

methyl iodide

1,4-dihydro-4-(3-aminophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid,dimethyl ester

Downstream raw materials:

4-[3-[(3-chloropropylamino)carbonylmethylamino]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid dimethyl ester

Refernces

• 1、 -. "DIHYDROPYRIDINE NPY ANTAGONISTS: CYANOGUANIDINE DERIVATIVES". . . Retrieved 2008/06/13.