2-formyl-3-pyridinecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-formyl-3-pyridinecarboxylic acid ethyl ester
• CAS No.: 21908-07-6
• Molecular Formula: C9H9NO3
• Molecular Weight: 179.175
• Hs Code.: 2933399090
• Mol file: 21908-07-6.mol

Synonyms:3-Pyridinecarboxylic acid,2-formyl-,ethyl ester;Ethyl 2-formylnicotinate;

Chemical Property of 2-formyl-3-pyridinecarboxylic acid ethyl ester

Chemical Property:

• PSA: 56.26000
• LogP: 1.07080
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-formylnicotinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-formyl-3-pyridinecarboxylic acid ethyl ester

There total 7 articles about 2-formyl-3-pyridinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 2-methyl nicotinate (1721-26-2) → 2-formyl-3-pyridinecarboxylic acid ethyl ester (21908-07-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water;

Reference yield: 36.8%

dichloromethane (75-09-2) + 2,3-diethyl pyridinedicarboxylate (2050-22-8) → 2-formyl-3-pyridinecarboxylic acid ethyl ester (21908-07-6)

Guidance literature:

In diisobutylaluminium hydride; ethyl acetate; toluene;

Reference yield: 35.0%

Ethyl 2-diethoxymethylnicotinate (23504-40-7) → 2-formyl-3-pyridinecarboxylic acid ethyl ester (21908-07-6)

Guidance literature:

With hydrogenchloride; water; In acetone; at 20 ℃; for 2h;

upstream raw materials:

2,3-diethyl pyridinedicarboxylate

Ethyl 2-diethoxymethylnicotinate

3-amino-4,4-diethoxycrotonic acid ethyl ester

ethyl 2-methyl nicotinate

Downstream raw materials:

7H-furo[3,4-b]pyridin-5-one

(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid methyl ester

(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoic acid

(3S)-4-cyclohexyl-2-hydroxy-3-<<(2S)-4-methyl-2-<<(2S)-2-(5-oxo-5,7-dihydropyrrolo<3,4-b>pyridin-6-yl)-3-phenylpropionyl>amino>pentanoyl>amino>butyric acid methyl ester