Technology Process of 6-Oxo-3-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-1(6H)-pyridazinebutyric acid
There total 6 articles about 6-Oxo-3-(2-phenylpyrazolo(1,5-a)pyridin-3-yl)-1(6H)-pyridazinebutyric acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
water;
at 40 ℃;
for 2h;
Large scale;
DOI:10.1021/op980039c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium hydroxide / dichloromethane; water / 1 h / 5 - 25 °C / Large scale
2: acetic acid / 1,2-dimethoxyethane; ethyl acetate / 6 h / 90 - 95 °C
3: hydrazine hydrate / water / 2 h / 105 - 110 °C / Large scale
4: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / 1,2-dimethoxyethane; methanol / 4 h / 50 - 55 °C
5: sodium hydroxide / water / 2 h / 40 °C / Large scale
With
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; sodium hydroxide;
In
methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;
2: |Aldol Condensation;
DOI:10.1021/op980039c
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid / 1,2-dimethoxyethane; ethyl acetate / 6 h / 90 - 95 °C
2: hydrazine hydrate / water / 2 h / 105 - 110 °C / Large scale
3: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / 1,2-dimethoxyethane; methanol / 4 h / 50 - 55 °C
4: sodium hydroxide / water / 2 h / 40 °C / Large scale
With
N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; hydrazine hydrate; acetic acid; sodium hydroxide;
In
methanol; 1,2-dimethoxyethane; water; ethyl acetate;
1: |Aldol Condensation;
DOI:10.1021/op980039c
