1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone

Base Information

• Chemical Name: 1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone
• CAS No.: 122643-81-6
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30443784
• Nikkaji Number: J1.126.040C
• Wikidata: Q82261732
• Mol file: 122643-81-6.mol

Synonyms:122643-81-6;1-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone;1-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)ethanone;Ethanone, 1-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-;2-phenyl-3-acetylpyrazolo[1,5-a]pyridine;1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)ethan-1-one;1-{2-phenylpyrazolo[1,5-a]pyridin-3-yl}ethan-1-one;SCHEMBL7665680;DTXSID30443784;LAGKMXIFTIXARS-UHFFFAOYSA-N;XEA64381;MFCD09759184;AKOS015840527;CE-0100;3-acetyl-2-phenylpyrazolo[1,5-a]pyridine;2-phenyl-3-acetylpyrazolo-[1,5-a]pyridine;CS-0443029;J-503059

Chemical Property of 1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone

Chemical Property:

• PSA: 34.37000
• LogP: 3.20390
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 236.094963011
• Heavy Atom Count: 18
• Complexity: 312

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)C1=C2C=CC=CN2N=C1C3=CC=CC=C3

Technology Process of 1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone

There total 5 articles about 1-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-aminopyridin-1-ium iodide (6295-87-0) + 4-phenyl-3-butyne-2-one (1817-57-8) → 2-phenyl-3-acetylpyrazolo[1,5-a]pyridine (122643-81-6)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 5 - 25 ℃; for 1h; Solvent; Large scale;

DOI:10.1021/op980039c

Reference yield: 74.0%

N-aminopyridin-1-ium iodide (6295-87-0) + 1-Phenylbut-1-en-3-one (122-57-6) → 2-phenyl-3-acetylpyrazolo[1,5-a]pyridine (122643-81-6)

Guidance literature:

With oxygen; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 24h;

DOI:10.1055/s-0036-1588753

Reference yield: 59.0%

→ 2-phenyl-3-acetylpyrazolo[1,5-a]pyridine (122643-81-6)

Guidance literature:

With potassium carbonate; potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 6h;

upstream raw materials:

1-aminopyridinium mesitylenesulphonate

4-phenyl-3-butyne-2-one

2-phenylpyrazolo[1,5-a]pyridine

N-aminopyridin-1-ium iodide

Downstream raw materials:

3-(1-hydroxyethyl)-2-phenylpyrazolo<1,5-a>pyridine

C₁₅H₁₁BrN₂O

3-(3-oxo-2,3-dihydropyridazin-6-yl)-2-phenylpyrazolo<1,5-a>pyridine

3-[2-(3-carboxypropyl)-3-oxo-2,3-dihydropyridazin-6-yl]-2-phenylpyrazolo[1,5-a]pyridine