(E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

Base Information

Chemical Name:(E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid
CAS No.:219964-34-8
Molecular Formula:C16H14N2O3
Molecular Weight:282.299
Hs Code.:
Mol file:219964-34-8.mol

Synonyms:Benzoic acid, 4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl]- (9CI);Benzoic acid, 4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-;

Suppliers and Price of (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
E-4-((3-(Pyridin-3-yl)acrylamido)methyl)benzoicAcid
500mg
$ 580.00

TRC
E-4-((3-(Pyridin-3-yl)acrylamido)methyl)benzoicAcid
100mg
$ 160.00

Total 4 raw suppliers

Chemical Property of (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

Chemical Property:

PSA：79.29000
LogP:2.50030

Purity/Quality:

Purity more than 98% ^*data from raw suppliers

E-4-((3-(Pyridin-3-yl)acrylamido)methyl)benzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses E-4-((3-(Pyridin-3-yl)acrylamido)methyl)benzoic Acid acts as a reagent for the synthesis of chidamide, a new histone deacetylase (HDAC) inhibitor.

Technology Process of (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

There total 4 articles about (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 56-91-7
p-aminomethylbenzoic acid

: 19337-97-4,1126-74-5
trans-3-(3-pyridyl)acrylic acid

: 219964-34-8
4-[N-(pyridin-3-ylacryloyl)aminomethyl]benzoic acid

Guidance literature:: trans-3-(3-pyridyl)acrylic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

p-aminomethylbenzoic acid; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 8h;

Reference yield: 67.6%

: 56-91-7
p-aminomethylbenzoic acid

: 219964-34-8
4-[N-(pyridin-3-ylacryloyl)aminomethyl]benzoic acid

Guidance literature:: p-aminomethylbenzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

p-aminomethylbenzoic acid; With sodium hydroxide; In acetonitrile; at 60 ℃;

With hydrogenchloride; In water; acetonitrile; pH=7;

Reference yield: 67.6%

: 56-91-7
p-aminomethylbenzoic acid

: 1126-74-5
3-(pyridin-3-yl)acrylic acid

: 219964-34-8
4-[N-(pyridin-3-ylacryloyl)aminomethyl]benzoic acid

Guidance literature:: 3-(pyridin-3-yl)acrylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 0.5h;

p-aminomethylbenzoic acid; With sodium hydroxide; In water; acetonitrile; at 60 ℃; for 1h;

With hydrogenchloride; In water; acetonitrile; pH=7;