poly 8-bromoadenylic acid

Base Information

• Chemical Name: poly 8-bromoadenylic acid
• CAS No.: 50828-34-7
• Molecular Formula: C₁₀H₁₃BrN₅O₇P
• Molecular Weight: 426.12
• Mol file: 50828-34-7.mol

Synonyms:Poly(8-bromoadenylicacid)

Chemical Property of poly 8-bromoadenylic acid

Chemical Property:

• Boiling Point: 834.8°Cat760mmHg
• Flash Point: 458.7°C
• Density: 2.62g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of poly 8-bromoadenylic acid

There total 4 articles about poly 8-bromoadenylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) → 8-bromoadenosine-5'-monophosphate (23567-96-6,50828-34-7)

Guidance literature:

With potassium dihydrogenphosphate; bromine; In water; at 20 ℃; pH=5; Inert atmosphere;

DOI:10.1039/c1cc15499k

Reference yield: 14.0%

8-bromoadenosine (2946-39-6) → 8-bromoadenosine-5'-monophosphate (23567-96-6,50828-34-7)

Guidance literature:

With pyridine; water; trichlorophosphate; In various solvent(s); at 2 - 4 ℃;

DOI:10.1039/b614477b

Reference yield:

8-bromoadenosine (2946-39-6) → 8-bromoadenosine-5'-monophosphate (23567-96-6,50828-34-7) + 8-chloroadenosine 5′-monophosphate (37676-40-7)

Guidance literature:

With triethyl phosphate; trichlorophosphate; at 0 ℃; for 1h; Overall yield = 68 %; Overall yield = 54.1 mg;

DOI:10.1021/acs.joc.7b02749

upstream raw materials:

8-bromoadenosine

5'-adenosine monophosphate

Refernces

• 1、 Moreau, Christelle,Ashamu, Gloria A.,Bailey, Victoria C.,Galione, Antony,Guse, Andreas H.,Potter, Barry V. L.. "Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: A C2′ endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor". experimental part. p. 278 - 290. Retrieved 2011/02/23.
• 2、 Collier, Alice,Wagner, Gerd. "A facile two-step synthesis of 8-arylated guanosine mono- and triphosphates (8-aryl GXPs)". . p. 4526 - 4532. Retrieved 2008/09/19.