2,5-Di-tert-butylbenzene-1,4-diamine

Base Information

• Chemical Name: 2,5-Di-tert-butylbenzene-1,4-diamine
• CAS No.: 22162-01-2
• Molecular Formula: C14H24N2
• Molecular Weight: 220.358
• DSSTox Substance ID: DTXSID10577051
• Wikidata: Q82466970
• Mol file: 22162-01-2.mol

Synonyms:2,5-di-tert-butylbenzene-1,4-diamine;22162-01-2;2,5-ditert-butylbenzene-1,4-diamine;1,4-Benzenediamine, 2,5-bis(1,1-dimethylethyl)-;4-amino-2,5-ditert-butylphenylamine;SCHEMBL2153631;DTXSID10577051;AE-562/43458653

Chemical Property of 2,5-Di-tert-butylbenzene-1,4-diamine

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.193948774
• Heavy Atom Count: 16
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC(=C(C=C1N)C(C)(C)C)N

Technology Process of 2,5-Di-tert-butylbenzene-1,4-diamine

There total 5 articles about 2,5-Di-tert-butylbenzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-di-tert-butyl-p-dinitrobenzene (10472-70-5) → 2,5-di-tert-butylbenzene-1,4-diamine (22162-01-2)

Guidance literature:

With nickel; isopropyl alcohol; at 100 ℃; under 58840.6 Torr; Hydrogenation;

DOI:10.1021/ja01201a001

Reference yield:

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2,5-di-tert-butylbenzene-1,4-diamine (22162-01-2)

Guidance literature:

Multi-step reaction with 5 steps

1: H₂SO₄

2: AlCl₃ / 45 °C

3: glacial acetic acid; acetic acid anhydride; HNO₃ / 30 - 40 °C

4: HNO₃ / 60 °C

5: nickel; propanol-⁽²⁾ / 100 °C / 58840.6 Torr / Hydrogenation

With aluminium trichloride; sulfuric acid; nitric acid; acetic anhydride; nickel; acetic acid; isopropyl alcohol;

DOI:10.1021/ja01201a001

Reference yield:

2,5-di-tert-butylnitrobenzene (3463-35-2) → 2,5-di-tert-butylbenzene-1,4-diamine (22162-01-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃ / 60 °C

2: nickel; propanol-⁽²⁾ / 100 °C / 58840.6 Torr / Hydrogenation

With nitric acid; nickel; isopropyl alcohol;

DOI:10.1021/ja01201a001

upstream raw materials:

2,5-di-tert-butyl-p-dinitrobenzene

2,5-di-tert-butylnitrobenzene

1,4-di-tert-butylbenzene

benzene

Downstream raw materials:

2,5-di-tert-butyl-[1,4]benzoquinone-bis-bromoimine

1,4-di-tert-butyl-2,5-diiodobenzene

2,5-Di-(N-nitrosacetamido)-1,4-di-t-butylbenzol

2,5-di-tert-butyl-p-benzoquinone