Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester

Base Information

Chemical Name:Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester
CAS No.:223126-68-9
Molecular Formula:C25H26O4
Molecular Weight:390.479
Hs Code.:
Mol file:223126-68-9.mol

Synonyms:2-Phenoxy-3-(4-benzyloxyphenyl)-2-methyl-propionic Acid Ethyl Ester;3-(4-Benzyloxy-phenyl)-2-methyl-2-phenoxy-propionic acid ethyl ester;ethyl 3-(4-benzyloxyphenyl)-2-methyl-2-phenoxypropionate;

Suppliers and Price of Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester

Chemical Property:

PSA：44.76000
LogP:5.20890

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester

There total 5 articles about Benzenepropanoic acid, a-methyl-a-phenoxy-4-(phenylmethoxy)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 401468-50-6
3-(4-benzyloxyphenyl)-3-hydroxy-2-phenoxy-2-methylpropionic acid ethyl ester

: 223126-68-9
2-phenoxy-3-(4-benzyloxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: ammonium chloride

: 223126-69-0
3-(4-hydroxyphenyl)-2-methyl-2-phenoxypropionic acid ethyl ester

: 401468-50-6
3-(4-benzyloxyphenyl)-3-hydroxy-2-phenoxy-2-methylpropionic acid ethyl ester

: 223126-68-9
2-phenoxy-3-(4-benzyloxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; ethyl acetate;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 223126-68-9
2-phenoxy-3-(4-benzyloxyphenyl)-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; cyclohexane / 0.08 h / -78 °C

1.2: tetrahydrofuran; cyclohexane / 0.17 h

2.1: 1.34 g / BF₃*Et₂O; triethylsilane / CH₂Cl₂ / 2 h

With triethylsilane; boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/jm0342616