1,5-Bis(3-methoxyphenyl)pentan-3-one

Base Information

• Chemical Name: 1,5-Bis(3-methoxyphenyl)pentan-3-one
• CAS No.: 223137-67-5
• Molecular Formula: C19H22O3
• Molecular Weight: 298.382
• DSSTox Substance ID: DTXSID00573284
• Nikkaji Number: J2.324.039D
• Wikidata: Q82461931
• Mol file: 223137-67-5.mol

Synonyms:1,5-bis(3-methoxyphenyl)pentan-3-one;223137-67-5;3-Pentanone, 1,5-bis(3-methoxyphenyl)-;SCHEMBL7332474;DTXSID00573284

Chemical Property of 1,5-Bis(3-methoxyphenyl)pentan-3-one

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 298.15689456
• Heavy Atom Count: 22
• Complexity: 299

Purity/Quality:

99%,98%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)CCC(=O)CCC2=CC(=CC=C2)OC

Technology Process of 1,5-Bis(3-methoxyphenyl)pentan-3-one

There total 4 articles about 1,5-Bis(3-methoxyphenyl)pentan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-(2-chloroethyl)-3-methoxybenzene (73004-96-3) + chloroformic acid ethyl ester (541-41-3) → 1,5-bis(3-methoxyphenyl)-3-pentanone (223137-67-5)

Guidance literature:

With [2,2]bipyridinyl; chloro-trimethyl-silane; nickel(II) bromide 2-methoxyethyl ether complex; zinc; In tetrahydrofuran; N,N-dimethyl acetamide; at 40 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201903330

Reference yield:

(1E,4E)-1,5-bis(3-methoxyphenyl)penta-1,4-dien-3-one (458533-66-9) → 1,5-bis(3-methoxyphenyl)-3-pentanone (223137-67-5) + 1,5-bis-(3-methoxy-phenyl)-pentan-3-ol

Guidance literature:

With hydrogen; nickel; In acetone; for 24h; under 760 Torr; Yield given; Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0957-4166(98)00481-9

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → 1,5-bis(3-methoxyphenyl)-3-pentanone (223137-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / aq. NaOH / ethanol / 2 h / Ambient temperature

2: H₂ / Raney Ni / acetone / 24 h / 760 Torr / Ambient temperature

With sodium hydroxide; hydrogen; nickel; In ethanol; acetone;

DOI:10.1016/S0957-4166(98)00481-9

upstream raw materials:

(1E,4E)-1,5-bis(3-methoxyphenyl)penta-1,4-dien-3-one

3-methoxy-benzaldehyde

1-(2-chloroethyl)-3-methoxybenzene

chloroformic acid ethyl ester

Downstream raw materials:

(R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol

(R)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol

2,2′,3,3′-tetrahydro-1,1′-spirobi[indene]-7,7′-diol

1,5-bis(3-methoxyphenyl)pentane