73004-96-3

Usage

Uses

Used in Pharmaceutical Industry:
(3-(2-CHLOROETHYL)PHENYL)METHANOL is used as a key intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds.
Used in Organic Synthesis:
(3-(2-CHLOROETHYL)PHENYL)METHANOL serves as a building block for organic synthesis, contributing to the creation of a wide range of organic compounds.
Used as a Reagent:
(3-(2-CHLOROETHYL)PHENYL)METHANOL is also employed as a reagent in chemical reactions, facilitating specific transformations and processes in the laboratory.
Safety Measures:
It is essential to handle (3-(2-CHLOROETHYL)PHENYL)METHANOL with care due to its moderately hazardous nature. Potential health effects include irritation to the skin, eyes, and respiratory system, along with possible long-term health impacts from prolonged or repeated exposure. Appropriate safety measures should be implemented during its use and handling.

InChI:InChI=1/C9H11ClO/c1-11-9-4-2-3-8(7-9)5-6-10/h2-4,7H,5-6H2,1H3

Upstream product

• 5020-41-7 2-(3-methoxyphenyl)-ethanol 
• 25112-95-2 toluene-4-sulfonic acid 2-(3-methoxyphenyl)-ethyl ester 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 6971-51-3 3-methoxybenzyl alcohol 
• 35553-92-5 ETHYL 3-METHOXYPHENYLACETATE 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 75534-19-9 2-(2-bromo-5-methoxyphenyl)ethyl chloride 
• 824-98-6 m-methoxybenzyl chloride 
• 100-83-4 meta-hydroxybenzaldehyde 
• 1798-09-0 m-methoxyphenylacetic acid 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 

Downstream Products

• 25226-97-5 3-methoxyphenethyl iodide 
• 28438-25-7 1-(3-methoxy-phenethyl)-cyclohexanol 
• 121119-85-5 1,2-dihydro-1-<2-(3-methoxyphenyl)ethyl>cyclobutabenzen-1-ol 
• 76705-56-1 3-(3-Methoxy-phenyl)-1-[2-methyl-3-(2-methyl-[1,3]dioxolan-2-yl)-cyclopent-1-enyl]-propan-1-ol 
• 76107-49-8 N-{1-[2-(3-Methoxy-phenyl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide 
• 1027091-33-3 2-{1-[2-(3-Methoxy-phenyl)-ethyl]-piperidin-4-yl}-1H-benzoimidazole 
• 137406-49-6 3-(2-m-methoxyphenylethylidene)isoindolinone 
• 76107-52-3 N-(1-(3-hydroxyphenylethyl)piperidin-4-yl)-N-phenylpropionamide 
• 76685-89-7 2-{3-[3-(3-Methoxy-phenyl)-prop-(E)-ylidene]-2-methyl-2-vinyl-cyclopentyl}-2-methyl-[1,3]dioxolane 
• 76685-91-1 (3aR,4R,7aR)-4-[2-(3-Methoxy-phenyl)-ethyl]-7a-methyl-1-(2-methyl-[1,3]dioxolan-2-yl)-octahydro-inden-5-one 
• 412321-30-3 3-(2-cyclohex-1-enyl-ethyl)-anisole 
• 857590-54-6 1-(2-cyclohexylethyl)-3-methoxybenzene 
• 52831-89-7 5-(3-methoxy-phenyl)-pentan-2-one 
• 2146-60-3 ethyl 2-acetyl-4-(3-methoxyphenyl)butanoate 

Relevant academic research and scientific papers

Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'

A novel central nervous system (CNS) selective neurokinin-1 (NK1) receptor antagonist, (2S,3S)-3-[(1R)-6-methoxy-1-methyl-1-trifluoromethylisochroman-7-yl]-methylamino-2-phenylpiperidine 'CJ-17,493' (compound (+)-1), was synthesized stereoselectively using a kinetic resolution by lipase-PS as a key step. Compound (+)-1 displayed high and selective affinity (Ki = 0.2 nM) for the human NK1 receptor in IM-9 cells, potent activity in the [Sar9, Met(O2)11]SP-induced gerbil tapping model (ED50 = 0.04 mg/kg, sc) and in the ferret cisplatin (10 mg/kg, ip)-induced anti-emetic activity model (vomiting: ED90 = 0.07 mg/kg, sc), all levels of activity comparable with those of CP-122,721. In addition, compound (+)-1 exhibited linear pharmacokinetics rather than the super dose-proportionality of CP-122,721 and this result provides a potential solution for the clinical issue observed with CP-122,721.

Prostanoids and related compounds. VI. Synthesis of isoindolinone derivatives possessing inhibitory activity for thromboxane A2 analog (U- 46619)-induced vasoconstriction

We have synthesized 3-(o, m or p-substituted benzylidene)isoindolinone and 3-(2-o, m or p-substituted phenylethylidene)isoindolinone, which possess inhibitory activity for thromboxane A2 analog (U-46619)-induced vasoconstriction.