2-Chloro-6-methoxynaphthalene

Base Information

• Chemical Name: 2-Chloro-6-methoxynaphthalene
• CAS No.: 67886-68-4
• Molecular Formula: C11H9ClO
• Molecular Weight: 192.645
• Hs Code.: 2909309090
• European Community (EC) Number: 267-555-0
• DSSTox Substance ID: DTXSID50987251
• Nikkaji Number: J287.625F
• Wikidata: Q82975461
• Mol file: 67886-68-4.mol

Synonyms:2-Chloro-6-methoxynaphthalene;67886-68-4;EINECS 267-555-0;2-methoxy-6-chloronaphthalene;SCHEMBL7694434;DTXSID50987251;DFJBXCAVJOGNDS-UHFFFAOYSA-N;Naphthalene, 2-chloro-6-methoxy-;AKOS017516219;FT-0706953

Chemical Property of 2-Chloro-6-methoxynaphthalene

Chemical Property:

• Vapor Pressure: 0.00162mmHg at 25°C
• Boiling Point: 303.9°Cat760mmHg
• Flash Point: 139.4°C
• PSA: 9.23000
• Density: 1.207g/cm³
• LogP: 3.50180
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 192.0341926
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-6-methoxynaphthalene 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=C(C=C2)Cl

Technology Process of 2-Chloro-6-methoxynaphthalene

There total 2 articles about 2-Chloro-6-methoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Bromo-6-methoxynaphthalene (5111-65-9) → 6-chloro-2-methoxynaphthalene (67886-68-4)

Guidance literature:

With copper(l) iodide; copper(l) chloride; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 12h; Inert atmosphere;

Reference yield:

→ 6-chloro-2-methoxynaphthalene (67886-68-4)

Guidance literature:

6-Amino-2-methoxy-naphthalin in konz. HCl, NaNO2; Diazonium-Salz, CuCl/konz. HCl;

DOI:10.1007/BF00778055

Reference yield: 92.0%

ortho-tolylmagnesium bromide (932-31-0) + 6-chloro-2-methoxynaphthalene (67886-68-4) → 6-(2-methylphenyl)-2-naphthyl methyl ether

Guidance literature:

6-chloro-2-methoxynaphthalene; With Ni(PPh₃)(1,3-di-tert-butylimidazol-2-ylidene)Br₂; In tetrahydrofuran; at 0 ℃; for 0.0333333h; Inert atmosphere; Schlenk technique;

ortho-tolylmagnesium bromide; In tetrahydrofuran; at 0 - 25 ℃; for 5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.5b00874

upstream raw materials:

2-Bromo-6-methoxynaphthalene

Downstream raw materials:

(R,S) naproxen ethyl ester

2-butyl-6-methoxynaphthalene