Naproxen Ethyl Ester

Base Information

• Chemical Name: Naproxen Ethyl Ester
• CAS No.: 31220-35-6
• Molecular Formula: C16H18O3
• Molecular Weight: 258.317
• European Community (EC) Number: 641-915-0
• UNII: 978RJD689Y
• DSSTox Substance ID: DTXSID20185146
• Mol file: 31220-35-6.mol

Synonyms:(S)-naproxen ethyl ester

Chemical Property of Naproxen Ethyl Ester

Chemical Property:

• Refractive Index: 1.5400 (estimate)
• Boiling Point: 361.57°C (rough estimate)
• PSA: 35.53000
• Density: 1.1090 (rough estimate)
• LogP: 3.51500
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Water Solubility.: 1.2mg/L(21 oC)
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 258.125594432
• Heavy Atom Count: 19
• Complexity: 302

Purity/Quality:

99.90% ^*data from raw suppliers

(S)-NaproxenEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)C1=CC2=C(C=C1)C=C(C=C2)OC
• Isomeric SMILES: CCOC(=O)[C@@H](C)C1=CC2=C(C=C1)C=C(C=C2)OC
• Uses: Naproxen (N377520) ethyl derivative. Naproxen impurity.

Technology Process of Naproxen Ethyl Ester

There total 34 articles about Naproxen Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + naproxen (23981-80-8) → (R,S) naproxen ethyl ester (31220-35-6,84890-24-4,84890-25-5,37961-57-2)

Guidance literature:

With sulfuric acid;

Reference yield: 100.0%

ethanol (64-17-5) + (2S)-2-(6-methoxy(2-naphthyl))propanoic acid (22204-53-1) → (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid ethyl ester (31220-35-6)

Guidance literature:

With sulfuric acid;

Reference yield: 95.0%

ethyl 2-methylthio-2-(6-methoxy-2-naphthyl)propionate (84016-41-1) → (R,S) naproxen ethyl ester (31220-35-6,84890-24-4,84890-25-5,37961-57-2)

Guidance literature:

With nickel;

DOI:10.1016/S0040-4039(00)81701-3

upstream raw materials:

ethanol

naproxen

ethyl 2-methylthio-2-(6-methoxy-2-naphthyl)propionate

6-chloro-2-methoxynaphthalene

Downstream raw materials:

naproxen

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(R)-6-methoxy-α-methyl-2-naphthaleneacetic acid ethyl ester

(R)-2-(6-methoxy-2-naphthyl)propionic acid

Refernces

• 1、 ünal, G?khan,Atalay, P?nar,Ayd?n, ?mer,Dayan, Serkan,Han, M. ?hsan,Kü?ükgüzel, ?. Güniz,Tun?, Cansu ümran. "Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models". . . Retrieved 2021.
• 2、 Hagras, Mohamed,Saleh, Marwa A.,Ezz Eldin, Rogy R.,Abuelkhir, Abdelrahman A.,Khidr, Emad Gamil,El-Husseiny, Ahmed A.,El-Mahdy, Hesham A.,Elkaeed, Eslam B.,Eissa, Ibrahim H.. "1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies". . p. 380 - 396. Retrieved 2021/12/24.
• 3、 Kourounakis, Angeliki,Lambrinidis, George,Tzara, Ariadni. "Design of multifaceted antioxidants: Shifting towards anti-inflammatory and antihyperlipidemic activity". . . Retrieved 2021/08/30.