Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)-

Base Information

• Chemical Name: Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)-
• CAS No.: 22747-91-7
• Molecular Formula: C18H14N2O4
• Molecular Weight: 322.32
• DSSTox Substance ID: DTXSID70480517
• Mol file: 22747-91-7.mol

Synonyms:22747-91-7;N-(1-BENZOYL-2,4-DIOXOPYRROLIDIN-3-YL)BENZAMIDE;Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)-;DTXSID70480517;1-benzoyl-3-benzamidopyrrolidine-2,4-dione

Chemical Property of Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)-

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 322.09535693
• Heavy Atom Count: 24
• Complexity: 533

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)C(C(=O)N1C(=O)C2=CC=CC=C2)NC(=O)C3=CC=CC=C3

Technology Process of Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)-

There total 8 articles about Benzamide, N-(1-benzoyl-2,4-dioxo-3-pyrrolidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl hippurate (1499-53-2) → 1-benzoyl-3-benzoylamino-pyrrolidine-2,4-dione (22747-91-7) + 2,4-bis-benzoylamino-cyclobutane-1,3-dione (859821-27-5)

Guidance literature:

With sodium ethanolate; at 160 - 170 ℃;

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + acetic anhydride (108-24-7) + butanone (78-93-3) → 1-benzoyl-3-benzoylamino-pyrrolidine-2,4-dione (22747-91-7)

Guidance literature:

With sodium acetate;

DOI:10.1021/jo01154a016

Reference yield:

methyl magnesium iodide (917-64-6) + 2-phenylazlactone (1199-01-5,53766-22-6) → 1-benzoyl-3-benzoylamino-pyrrolidine-2,4-dione (22747-91-7)

Guidance literature:

With diethyl ether;

upstream raw materials:

α-picoline

2-phenylazlactone

methyl magnesium iodide

diethyl ether

Downstream raw materials:

3-benzoylamino-pyrrolidine-2,4-dione

benzoic acid