4,6-dimethyl-3,6-dihydro-2H-pyran-2-one

Base Information

• Chemical Name: 4,6-dimethyl-3,6-dihydro-2H-pyran-2-one
• CAS No.: 22936-96-5
• Molecular Formula: C7H10O2
• Molecular Weight: 126.155
• DSSTox Substance ID: DTXSID50481966
• Nikkaji Number: J1.736.431F
• Mol file: 22936-96-5.mol

Synonyms:4,6-dimethyl-3,6-dihydro-2H-pyran-2-one;22936-96-5;2H-Pyran-2-one, 3,6-dihydro-4,6-dimethyl-;SCHEMBL17308874;DTXSID50481966;4,6-dimethyl-3,6-dihydro-pyran-2-one

Chemical Property of 4,6-dimethyl-3,6-dihydro-2H-pyran-2-one

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 126.068079557
• Heavy Atom Count: 9
• Complexity: 158

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=C(CC(=O)O1)C

Technology Process of 4,6-dimethyl-3,6-dihydro-2H-pyran-2-one

There total 1 articles about 4,6-dimethyl-3,6-dihydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid (64-19-7,77671-22-8) + trans-3-penten-2-one (3102-33-8) → 5-Hydroxy-3,5-dimethyl-3-hexenoic Acid Lactone (22954-83-2) + 4,6-Dimethyl-3,6-dihydro-2H-pyran-2-one (22936-96-5)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)87193-3

Reference yield: 29.5%

(E)-β-ionone (79-77-6,14901-07-6) + 4,6-Dimethyl-3,6-dihydro-2H-pyran-2-one (22936-96-5) → (2E,4E,8E/2Z,4E,8E)-7-hydroxy-7-methyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,8-trienoic acid (131189-98-5,131235-62-6)

Guidance literature:

With lithium diethylamide; In tetrahydrofuran; 1.) -70 deg C, 15 min; -70 to 0 deg C, 30 min; 2.) -70 deg C, 50 min; 25 deg C, 40 min;

DOI:10.1016/0040-4020(95)00114-N

Reference yield:

4,6-Dimethyl-3,6-dihydro-2H-pyran-2-one (22936-96-5) → all-trans-retinoic-acid (302-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.)Li-diethylamide / 1.)THF, 0 deg C, 2.)THF, r.t.

2: 95 percent / p-toluenesulfonic acid / CH₂Cl₂ / Heating

3: I₂

With lithium diethylamide; iodine; toluene-4-sulfonic acid; In dichloromethane;

DOI:10.1016/S0040-4039(00)97961-9

upstream raw materials:

acetic acid

trans-3-penten-2-one

Downstream raw materials:

(2E,4E,8E/2Z,4E,8E)-7-hydroxy-7-methyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,8-trienoic acid

all-trans-retinoic-acid

(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenoic acid