N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Base Information

Chemical Name:N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine
CAS No.:229476-53-3
Molecular Formula:C17H16BrN3O2
Molecular Weight:374.23200
Hs Code.:
DSSTox Substance ID:DTXSID60416148
Nikkaji Number:J1.615.649C
Wikidata:Q82225322
ChEMBL ID:CHEMBL447230
Mol file:229476-53-3.mol

Synonyms:4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline;EBE-A22;N-(3-bromophenyl)-6,7-dimethoxy-4-quinazolinamine;PD 153035;PD-153035;PD153035

Suppliers and Price of N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EBE-A22
2.5mg
$ 305.00

DC Chemicals
EBE-A22 >98%
250 mg
$ 800.00

DC Chemicals
EBE-A22 >98%
1 g
$ 1600.00

Crysdot
EBE-A22 98+%
100mg
$ 911.00

Crysdot
EBE-A22 98+%
10mg
$ 247.00

Crysdot
EBE-A22 98+%
5mg
$ 163.00

Crysdot
EBE-A22 98+%
50mg
$ 586.00

American Custom Chemicals Corporation
EBE-A 22 95.00%
5MG
$ 502.70

Total 13 raw suppliers

Chemical Property of N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

Chemical Property:

Boiling Point:507.3±50.0 °C(Predicted)
PKA:5.65±0.30(Predicted)
PSA：47.48000
Density:1.446±0.06 g/cm3(Predicted)
LogP:4.17740
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:373.04259
Heavy Atom Count:23
Complexity:387

Purity/Quality:

99%, ^*data from raw suppliers

EBE-A22 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=CC(=CC=C1)Br)C2=NC=NC3=CC(=C(C=C32)OC)OC
Uses EBE-A 22 is an epidermal growth factor receptor inhibitor EGFR, an important target for the treatment of cancer. Selective VEGFR-2 receptor tyrosine kinase inhibitors.

Technology Process of N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine

There total 2 articles about N-(3-bromophenyl)-6,7-dimethoxy-N-methylquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 591-19-5
m-Bromoaniline

: 13790-39-1
6,7-dimethoxy-4-chloroquinazoline

: 229476-53-3
EBE-A₂₂

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

With sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmcl.2011.01.137