benzyl N-[cyclohexyl(phenylsulfonyl)methyl]carbamate

Base Information

• Chemical Name: benzyl N-[cyclohexyl(phenylsulfonyl)methyl]carbamate
• CAS No.: 232598-56-0
• Molecular Formula: C21H25NO4S
• Molecular Weight: 387.49
• Mol file: 232598-56-0.mol

Synonyms:

Chemical Property of benzyl N-[cyclohexyl(phenylsulfonyl)methyl]carbamate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl N-[cyclohexyl(phenylsulfonyl)methyl]-carbamate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl N-[cyclohexyl(phenylsulfonyl)methyl]carbamate

There total 1 articles about benzyl N-[cyclohexyl(phenylsulfonyl)methyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

O-benzyl carbamate (621-84-1) + sodium benzenesulfonate (873-55-2) + cyclohexanecarbaldehyde (2043-61-0) → benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate (232598-56-0)

Guidance literature:

With formic acid; In methanol; water; for 72h;

DOI:10.1021/ol101681r

Reference yield: 82.0%

Allyl acetate (591-87-7) + benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate (232598-56-0) → N-Benzyloxycarbonyl-1-cyclohexylbut-3-enylamine (646480-73-1)

Guidance literature:

With manganese; (1,2-dimethoxyethane)dichloronickel(II); triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In dodecane; N,N-dimethyl acetamide; at 40 ℃; for 28h;

DOI:10.1055/s-0034-1379539

Reference yield:

malonic acid dibenzyl ester (15014-25-2) + 1-(phenylethynyl)naphthalen-2-ol (1396512-33-6) + benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate (232598-56-0) → C24H18O3S + C32H35NO6

Guidance literature:

malonic acid dibenzyl ester; benzyl (cyclohexyl(phenylsulfonyl)methyl)carbamate; With sodium carbonate; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; In dichloromethane; at 20 ℃;

1-(phenylethynyl)naphthalen-2-ol; With potassium fluoride; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; In chloroform; at 25 ℃;

DOI:10.1021/acs.orglett.8b02087

upstream raw materials:

O-benzyl carbamate

sodium benzenesulfonate

cyclohexanecarbaldehyde

Downstream raw materials:

N-Benzyloxycarbonyl-1-cyclohexylbut-3-enylamine

Refernces

• 1、 Ollevier, Thierry,Li, Zhiya. "Bismuth triflate-catalyzed addition of allylsilanes to N- alkoxycarbonylamino sulfones: Convenient access to 3-Cbz-protected cyclohexenylamines". supporting information; experimental part. p. 3251 - 3259. Retrieved 2010/04/24.