Technology Process of 1-(phenylethynyl)naphthalen-2-ol
There total 10 articles about 1-(phenylethynyl)naphthalen-2-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 5 h / 50 °C / Inert atmosphere
2: hydrogenchloride / tetrahydrofuran; water; isopropyl alcohol / 16 h / 20 °C / Inert atmosphere
With
hydrogenchloride; copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine;
In
tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/ol201986e
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C / Inert atmosphere
1.2: 24 h / 0 - 20 °C / Inert atmosphere
2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 50 °C / Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; isopropyl alcohol; water / 24 h / 20 °C / Inert atmosphere
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine;
In
tetrahydrofuran; water; isopropyl alcohol; mineral oil;
DOI:10.1039/c6cc01690a
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuric acid; dihydrogen peroxide; potassium iodide / methanol; water / 1.5 h / 0 - 25 °C
2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 25 °C
3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 6 h / 50 °C / Inert atmosphere
4: hydrogenchloride / methanol; water / 4 h / 25 °C
With
hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; dihydrogen peroxide; potassium carbonate; triethylamine; potassium iodide;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jacs.8b03211